Genetic moudlation and treatment response
The mesolimbic dopaminergic reward system is a key structure underlying addictive behaviour in alcohol addiction and is under control of prefrontal glutamatergic neurotransmission. The aim of the present multicenter-study in Berlin; Bonn and Mannheim is to use fMRI in alcohol addiction for endophenotyping in order to study the relevance of genectic variation, in particular in dopaminergic and glutamatergic genes, for addiction. We will use a temporal discounting and a cue reactivity paradigm in alcoholics and healthy controls in order to 1) test the impact of genetic variation on activation of the mesolimbic system in these populations and to 2) to test their predictive effects for treatment outcome in alcoholics. The subproject will thus bridge animal research on genetically determined cue reactivity and human studies in alcoholics. Furthermore, we will link our results to the measurement of glutamate and glutamine with magnetic resonance spectroscopy (MRS) in subproject SP14.
Projektleiter: A. Heinz, H. Walter, F. Kiefer
Förderer: Nationales Genomforschungsnetz (NGFN II/NGFN plus) |
