Genome-Wide Association Study of Alcohol Dependence

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Genome-wide Association Study of Alcohol Dependence(Treutlein, Cichon, Ridinger et al., 2009), Supplementary Online Content


a) supplementary eFigures:

(please click on figures below for high resolution versions)

eFigure 1. Before (A and B) and after (C and D) quality control quantile-quantile plots of the Cochran-Armitage trend test nominal (A and C) vs l-corrected (B and D) P values of autosomal single nucleotide polymorphisms (SNPs). The latter P values were corrected for stratification using the method developed by Devlin and Roeder. The SNPs at which the test statistic exceeds 30 are represented by triangles at the top of the plot. _____________________

eFigure 2. Illustration of P values in a ±60-kilobase interval around ADH1C rs1614972, which was selected for follow-up using the “rodent candidate gene” strategy. The grey shaded box contains clustered single nucleotide polymorphisms (SNPs). Gene annotations are from University of California Santa Cruz RefSeq genes; linkage disequilibrium maps are from the International HapMap Project.

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eFigure 3. Illustration of P values in a ±60-kilobase interval around CDH13 rs11640875, which was selected for follow-up using the “rodent candidate gene” strategy. The grey shaded box contains clustered single nucleotide polymorphisms (SNPs). Gene annotations are from University of California Santa Cruz RefSeq genes; linkage disequilibrium maps are from the International HapMap Project.

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eFigure 4. Illustration of P values in a ±60-kilobase interval around GATA4 rs13273672, which was selected for follow-up using the “rodent candidate gene” strategy. The grey shaded box contains clustered single nucleotide polymorphisms (SNPs). Gene annotations are from University of California Santa Cruz RefSeq genes; linkage disequilibrium maps are from the International HapMap Project.

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b) supplementary eTables

eTable 1
eTable 2
eTable 3
eTable 4
eTable 5

c) Supplementary Text