Head: Martin Bohus
Staff:
Melanie Domsalla, Anne Dyer PhD, Sonja Kiko, Nikolaus Kleindienst PhD, Matthias Limberger, Anna Mall, Kathlen Priebe, Joachim Wiskemann, Martin Jungkunz
Current Projects
Research Area: Borderline Personality Disorder
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Identification of Moderators and Mediators of Therapieresponse in DBT
Correlation between dissociative Experiences and Oligodipsia in BPD Patients
Evalutation of Long Term Efficacy in DBT
Martin Bohus, Nikolaus Kleindienst, Matthias Limberger
For patients it is essential whether the improvement of the disorder specific impairment through DBT treatment persist in the long term. To examine this question at the Freiburg University Hospital a 2 year study was carried out. First results of this study show a long term stabilisation in patient who achieved DBT. Stabilisation could be shown in borderline specific as well as general psychopathological symptomatic.
Validation of the Borderline Symptom List (BSL-95)
Martin Bohus, Matthias Limberger, Nikolaus Kleindienst, Melanie Domsalla
Funding: Borderline Personality Disorder Research Foundation (BPDRF)
For detailed Evaluation of borderline-symptomatic, well developed and evaluated measurements are needed. Our research unit developed and evaluated the BSL for this purpose. The BSL was developed for the quantitative Evaluation of subjective experience of mental impairment as well as dysfunctional behavior of patients with Borderline Personality Disorder (BPD). In a study with 380 Borderline patients the factor structure of the BSL-95 was determined and preliminary psychometric properties were examined. In the next steps the change sensitivity to measure therapeutic induced changes in disorder specific impairments must be examined and ensured. Therefore 300 BPD Patients have to complete the BSL-95 and a sample of 100 BPD Patients has to rate the BSL at the beginning and the end of a 3 month inpatient DBT treatment.
Download of the BSL-95 and more information here 
Development of the Short Version of the Borderline Symptom List (BSL-23)
Martin Bohus, Matthias Limberger, Nikolaus Kleindienst, Melanie Domsalla
For the detailed registration of the development of borderline-specific symptomatology (for example in therapy-studies) repeated measures are essential. To reduce patient burden, we developed the BSL-23. The BSL-23 is the short version of the BSL and includes only 23 Items of the 95 Items of the BSL-95. First studies to evaluate the psychometric properties show promising results.
Download of the BSL-23 and more Information here
Epidemiology and differential Psychopathology of BPD
DBT Stage II Treatment - Development of Screening Instruments
Social Interactions in patients with Borderline Personality Disorder
Melanie Domsalla, Julia Ziegler
Problems in social relationships are important features of borderline personality disorder. The aim of this project is to investigate mechanisms and neural correlates of the perception of social situations and interactions using functional magnetic resonance imaging (fMRI) and virtual reality (VR).
Research Area: Posttraumatic Stress Disorder (PTSD)
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DBT-PTSD: Dialectical Behavior Therapy for Patients with Posttraumatic Stress Disorder after Childhood Sexual Abuse
Martin Bohus, Anne Dyer, Antje Krüger, Kathlen Priebe, Regina Steil
Several randomised controlled trials have demonstrated the efficacy of the state of the art therapies in the treatment of Posttraumatic Stress Disorder (PTSD): Cognitive behavioral therapy and EMDR. Frequently, patients with PTSD and co-occurring Borderline Personality Disorder are not treated sufficiently. Hence we developed a Dialectical Behavior Therapy (DBT) Stage II Treatment for patients with this clinical pattern: DBT-PTSD. The treatment combines strategies of traumafocused cognitive behavioral therapy with strategies of DBT.
First pre-post-studies provide evidence on the efficacy of this treatment on patients with PTSD following childhood sexual abuse. To proof the efficacy of this treatment in comparison to a wait list, we carried out the PASA study within the budget of a DFG-funded randomised controlled trial. At this stage, we evaluate the data. The first results are promising.
Within the next step, we are developing the manual for DBT-PTSD in an out-patient setting.
Self-Recognition
Julia Ziegler
For testing how fast and exact a person is able to recognize oneself, a 3D model is generated using one or more portraits of the person. Then it is shown among those of other persons. When recognizing the own face, one of two buttons is pushed. Recording the error rate and the time needed gives you information about a person’s ability of self-recognition.
Research Area: Supervision
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Development of an Online-Supervision-System
Martin Bohus, Patricia Marnet, Kathlen Priebe, Matthias Limberger
Research Area: Socialphobia
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Efficacy, Efficiency, and Mechanisms of Change of a Stepped-Care Program with computer-based Self-Help Module in Patients with Social Anxiety Disorder.
Martin Bohus, Regina Steil, Christiane Hermann, Sonja Kiko, Anna Mall
Social Anxiety Disorder (SAD) is one of the most prevalent psychological disorders: 7 - 13% of the general population meet the criteria for SAD at least once in their life. Our main purpose in this study is to investigate the efficacy and efficiency of a stepped-care program (SCP) for patients suffering from SAD. The treatment starts with an eight-session computer-based self-help module with minimal therapist contact via Email. If patients are not remitted after this first step, they are offered a second and – if necessary – third step of treatment. Those comprise eight single face-to-face sessions guided by a therapist each. In a randomized controlled trial on 102 SAD patients, the SCP is compared to a standard treatment (ST) of 16 sessions guided by a therapist. Both SCP and ST are based on the cognitive therapy of Social Anxiety Disorder according to David M. Clark.
We expect the SCP being significantly more effective and (cost-) efficient than the ST. Moreover, mechanisms of change will be investigated: it is expected that a successful treatment independently from intervention format will have positive effects on improved social performance, reduced physiological arousal, reduced anxiety and dysfunctional cognitions, and reduced biased information processing. Prior and after every eighth treatment session as well as 3, 6, 9, and 12 months after the end of treatment, clinician ratings, self-report measures, and utilisation of health care institutions are assessed.
Research Area: Psychooncology
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Mindfulness-Based Stress Reduction (MBSR) and physical exercise for patients undergoing hematopoietic stem cell transplantation (HSCT): Effects on psychobiology and immune function in the context of the stress-coping-resilience-model
Martin Bohus, Joachim Wiskemann, Anja Brechenser, Alois Burkhard, Lars Hofmann, Theresa O´Neill, Rea Nies, Brunhilde Schumann-Schmid
Even when the procedures are successful, patients experience considerable physical, psychological and psychosocial stress before, during and after hematopoietic stem cell transplantation (HSCT). Several publications suggested that physical exercise therapy and other behaviorale strategies constitute potentially promising interventions to reduce such stress within the framework of HSCT because of its multidimensional effectiveness. The current study examines the differential effects of two interventions strategies (MBSR and physical exercise) before, during and after HSCT.
Funding: German José-Carreras Leukaemia Foundation (DJCLS)
Cooperation partners:
Department of Medicine V, University of Heidelberg, Germany
Prof. Ho, Prof. Dreger and Prof. Goldschmidt
Department of Medicine III, University of Mannheim, Germany
Prof. Hehlmann and Prof. Buchheidt
Deutsche Klinik für Diagnostik (DKD) Wiesbaden, Germany
PD Dr. Schwerdtfeger
German Cancer Research Centre (DKFZ)
Dr. Krakowski-Roosen
Institute for sport and sport science (ISSW), University of Heidelberg, Germany
Prof. Huber
Additional cooperation partners and sponsors:
• RECK-Technik GmbH & Co. KG, Betzenweiler
• OMRON Healthcare Europe, Mannheim
• novacare GmbH, Bad Dürkheim
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