Heike Tost, MD, PhD

Professional Career

1991-1999 - Diploma (M.Sc.) in Psychology, University of Koblenz-Landau
Diploma Thesis - "Obsessive-compulsive phenomena in Tourette`ssyndrome"
Ph.D. (Dr.phil.) - "Neurobiological foundation of motion perception deficits in schizophrenia: an fMRI study", Grade "with highest honor"
2000-2006 - Medical School, University of Heidelberg, Medical internship in Mannheim
2006 - Approbation
M.D. (Dr.med.) - "D2 antidopaminergic modulation of brain structure, brain function and behavior", Grade "with highest honor"

Professional Positions

October 2010 - Head, Research Group Systems Neuroscience in Psychiatry (before: Imaging in Psychiatry), Department of Psychiatry and Psychotherapy, Central Institute of Mental Health
2006-2010 - Postdoctoral research fellow, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, MD, USA ( Director: Prof. Dr. D. R. Weinberger)
2004-2006 - Postdoctoral research fellow, Department of Genetic Epidemiology in Psychiatry (Head: Prof. Dr. M. Rietschel) and Department of Neuroimaging (Director: Prof. Dr. Dr. F. A. Henn), Central Institute of Mental Health, Mannheim
1999-2004 - Graduate student, NMR Research in Psychiatry, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim (Director: Prof. Dr. Dr. F. A. Henn)
1994-2000 - Educational assistent, Residential Facility for Adults with Physical and Mental Disabilities, St. Paulusstift Landau.

Grants and Awards

2010 - "Independent Research Group in Neuroscience", German Federal Ministry for Education and Research (BMBF)
2006 - National Institutes of Health (NIH) - German Research Foundation (DFG) Research Career Transition Award
2004 - Postdoctoral fellowship grant, Rheinische Friedrich-Wilhelms-University Bonn (Research training group "Pathogenesis of diseases of the central nervous system")
2000-2003 - Graduate student fellowship grant, Evangelisches Studienwerk Villigst

Publications in preparation

• Tost H, Alam T, Geramita M, Rebsch C, Kolachana B, Dickinson D, Verchinski BA, Lemaitre H, Barnett AS, Weinberger DR, Marenco S. Impact of the BDNF Val66Met Polymorphism on White Matter Tract Integrity in Prefrontal Cognitive Circuits.
• Tost H, Rasetti R, Kolachana B, Mattay V, Alam T, Barnett AS, Marenco S, Weinberger DR. Selective impact of the 5-HTTLPR polymorphism on limbic fiber tract integrity in females.
• Tost H, Wolf RC, Zoltick B, Meyer-Lindenberg A. A dorsal motor resonance mechanism in humans encodes for movement complexity.

Journal Articals

• Tost H, Meyer-Lindenberg A (2011). A new, blue gene highlights glutamate and hippocampus in depression. Neuron, 70(2):171-2.
• Tost H, Meyer-Lindenberg A (2011). Dopamine - glutamate interactions: a neural convergence mechanism of common schizophrenia risk variants. Biol Psychiatry, 69(10):912-3.
• Tost H, Weinberger DR (2011). RELN rs7341475 and schizophrenia risk: confusing, yet somehow intriguing. Biol Psychiatry. 69(5): e19.
• Tost H, Meyer-Lindenberg A (2010). I fear for you: a role for serotonin in moral behavior. Proc Natl Acad Sci USA, 107(40): 17071-2.
• Tost H, Kolachana B, Hakimi S, Lemaitre H, Verchinski BA, Mattay VS, Weinberger DR, Meyer-Lindenberg A  (2010). A Common Allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proc Natl Acad Sci USA, 107(31):13936-41.
• Tost H, Braus DF, Hakimi S, Höhn F, Meyer-Lindenberg A (2010). Acute D₂ receptor blockade induces rapid, reversible remodeling in human cortical-striatal circuits. Nat Neurosci, 13(8):920-2.
• Tost H, Lipska BK, Vakkalanka R, Lemaitre H, Callicott JH, Mattay VS, Kleinman JE, Marenco S, Weinberger DR (2010). No effect of a common allelic variant in the Reelin gene on intermediate phenotype measures of brain structure, brain function and gene expression. Biol Psychiatry, 68(1):105-7.
• Tost H, Ruf M, Schmäl C, Schulze TG, Knorr C, Vollmert C, Böbhenz K, Ende G, Meyer-Lindenberg A, Henn FA, Rietschel M (2010). Prefrontal-temporal gray matter deficits in bipolar disorder patients with persecutory delusions. J Affect Disord 120(1-3):54-61.
• Gruber O, Tost H, Henseler I, Schmael C, Scherk H, Ende G, Ruf M, Falkai P, Rietschel M (2010). Pathological amygdala activation during working memory performance: Evidence for a pathophysiological trait marker in bipolar affective disorder. Hum Brain Mapp 31(1):115-25.
• Tost H, Meyer-Lindenberg A, Klein S, Schmitt A, Höhn F, Tenckhoff A, Ruf M, Ende G, Rietschel M, Henn FA, Braus DF (2006). D₂ antidopaminergic modulation of frontal lobe functions in healthy human subjects. Biol Psychiatry 60(11):1196-205.
• Schmitt A, Bertsch T, Henning U, Tost H, Klimke A, Henn FA, Falkai P (2005). Increased serum S100B in elderly, chronic schizophrenic patients: negative correlation with deficit symptoms. Schizophr Research 80(2-3): 305-13.
• Schmitt A, Bertsch T, Tost H, Bergmann A, Henning U, Klimke A, Falkai P (2005). Increased serum interleukin-1b and interleukin-6 in elderly, chronic schizophrenic patients on stable antipsychotic medication. Neuropsychiatr Dis Treat 1(2): 171-177.
• Tost H, Vollmert C, Brassen S, Schmitt A, Dressing H, Braus DF (2004). Pedophilia: neuropsychological evidence encouraging a brain network perspective. Med Hypothesis 63(3): 528-531.
• Brassen S, Braus DF, Weber-Fahr W, Tost H, Adler G (2004). Late-onset depression with mild cognitive deficits: a preclinical dementia syndrome? Dement Geriatr Cogn Disord 18(3-4): 271-7.
• Brassen S, Tost H, Höhn F, Weber-Fahr W, Klein S, Braus DF (2003). Haloperidol challenge in healthy subjects: a functional magnetic resonance imaging study. Neurosci Lett 340(3): 193-196.
• Tenckhoff A, Tost H, Braus DF (2002). Veränderte Wahrnehmung zeitlicher Relationen bei schizophrenen Psychosen: eine Pilotstudie. Nervenarzt 73: 428-33.
• Braus DF, Weber-Fahr W, Tost H, Ruf M, Henn FA (2002). Sensory information processing in neuroleptic-naive first-episode schizophrenic patients. A functional magnetic resonance imaging study. Arch Gen Psychiatry 59: 696-701.
• Braus DF, Ende G, Weber-Fahr W, Demirakca T, Tost H, Henn FA (2002). Functioning and neuronal viability of the anterior cingulate gyrus following antipsychotic treatment: MR-spectroscopy in chronic schizophrenia. Eur Neuropsychopharm 12(2): 145-52.

Reviews

• Tost H, Bilek E, Meyer-Lindenberg A (2011). Brain Connectivity in Imaging Genetics. NeuroImage, in press.
• Tost H, Alam T, Meyer-Lindenberg A (2010). Dopamine and psychosis: theory, pathomechanisms and intermediate phenotypes. Neurosci Biobehav Rev 34(5):689-700.
• Ende G, Demirakca T, Tost H (2006). The biochemistry of dysfunctional emotions: proton MR spectroscopic findings in major depressive disorder. Progr Brain Res 156: 481-501.
• Tost H, Ende G, Ruf M, Henn FA, Meyer-Lindenberg A (2005). Functional imaging research in schizophrenia. Int Rev Neurobiol 67: 95-118.
• Tost H, Meyer-Lindenberg A, Ruf M, Demirakca T, Grimm O, Henn FA, Ende G (2005). Zehn Jahre funktionelle Magnetresonanztomographie in der Schizophrenieforschung: von der Abbildung einfacher Informationsverarbeitungsprozesse zur molekulargenetisch orientierten Bildgebung. Radiologe 45(2): 113-23.
• Wolf I, Tost H, Ruf M, Schmidt MH, Ende G (2005). Bildgebende Darstellung neurokognitiver Dysfunktion bei der Aufmerkamkeitsdefizit-/ Hyperaktivitätsstörung. Radiologe 45: 169-77.
• Vollmert C, Tost H, Brassen S, Jatzko A, Braus DF (2004). Depression und moderne Bildgebung. Eine Übersicht des aktuellen Forschungsstandes zur Anwendung bildgebender Verfahren bei depressiven Störungen. Fortschr Neurol Psychiatr 72: 435-45.
• Braus DF, Brassen S, Weimer E, Tost H (2003). Funktionelle Kernspintomographie (fMRI) und Psychopharmakaeffekte: eine Standortbestimmung. Fortschr Neurol Psychiatr 71: 72-83.
• Braus DF, Tost H, Hirsch JG, Gass A (2001). Diffusions-Tensor-Bildgebung (DTI) und funktionelle Magnetresonanztomographie (fMRI) erweitern das Methodenspektrum in der psychiatrischen Forschung. Nervenarzt 72: 384-390.
• Braus DF, Ende G, Tost H, Weber-Fahr W, Jatzko A, Schmitt A, Demirakca T (2000). Funktionelle Kernspintomographie und Schizophrenie: Medikamenteneffekte, methodische Grenzen und Perspektiven. Nervenheilkunde 19: 121-128.
• Schmitt A, Weber-Fahr W, Jatzko A, Tost H, Henn F.A, Braus DF (2001). Aktueller Überblick über strukturelle Magnetresonanztomographie bei Schizophrenie. Fortschr Neurol Psychiatr 69: 105-115.
• Braus DF, Ende G, Weber-Fahr W, Tost H, Demirakca T, Schmitt A, Henn FA (2000). Neuroleptika und einfache Informationsverarbeitungsprozesse. Psycho 26: 97-101.

Case Studies

• Lenhard T, Brassen S, Tost H, Braus DF (2005). Long-term behavioral changes after unilateral stereotactic cingulotomy in a case of therapy-resistant dependence on alcohol. World J Biol Psychiatry 6: 264-266.
• Tost H, Wendt CS, Schmitt A, Heinz A, Braus DF (2004). Huntington's disease: phenomenological diversity of a neuropsychiatric condition challenging traditional neurological and psychiatric concepts. Am J Psychiatry 161: 28-34.
• Tost H, Schmitt A, Brassen S, Wendt CS, Braus DF (2004). Neuropsychiatrische Aspekte der Chorea Huntington: Vorstellung zweier Fälle und Literaturübersicht. Nervenarzt 75: 258-266.
• Weimer E, Ries S, Tost H, Braus D.F. (2003). Frontale Dysfunktion bei Chorea Huntington: neuropsychologische und therapeutische Aspekte. Psychiatr Prax 30: 33-36.
• Dressing H, Obergriesser T, Tost H, Kaumeier S, Ruf M, Braus DF (2001). Homosexuelle Pädophilie und funktionelle Netzwerke: eine fMRI-Fallstudie. Fortschr Neurol Psychiatr 69: 539-545.

Bookchapters

• Braus DF, Tost H, Demirakca T (2010). Bildgebende Verfahren bei psychischen Störungen. Chapter 6, 89-120. In Lautenbacher S, Gauggel S (eds.): Die Neuropsychologie psychischer Störungen. Second edition. Heidelberg, Springer.
• Tost H, Hakimi S, Meyer-Lindenberg A (2009). Dopamine dysfunction in schizophrenia: from genetic susceptibility to cognitive impairment. Chapter 10.4, 558-571. In: Iversen L, Iversen S Dunnett S, Bjorklund A (eds.): Dopamine Handbook. Oxford, Oxford University Press.
• Tost H, Hakimi S, Meyer-Lindenberg A (2009) Magnetic resonance imaging biomarkers in schizophrenia research. Chapter 23, 381-402. In: Ritsner MS (ed.): Neuropsychiatric Biomarkers, Endophenotypes, and Genes: Promises, Advances, and Challenges. Dordrecht, Springer.
• Tost H, Meyer-Lindenberg A (2009). Neuroimaging biomarkers in schizophrenia. In Turck CW (ed.): Biomarkers for psychiatric disorders. Chapter 11, 231-267. Heidelberg, Springer.
• Braus DF, Demirakca T, Tost H (2004). Bildgebende Verfahren bei psychischen Störungen. Chapter 6, 91-122. In Lautenbacher S, Gauggel S (eds.): Die Neuropsychologie psychischer Störungen. First edition. Heidelberg, Springer.

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