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Biostatistic

Head

Head

Prof. Dr. Stefan Wellek

Phone: +49 621 1703-6001

Fax: +49 621 1703-6005

e-mail

Assistant: Mireille Lukas
Phone: +49 621 1703-6002, e-mail

D 7, 27, Groundfloor, Room 03

Description

Within the research activities of the Department of Biostatistics two categories must be distinguished that differ markedly in terms of scientific content as well as in terms of required skills and technical prerequisites: The first category encompasses cooperative projects whose primary goal is to provide professional statistical and methodological expertise to a variety of research projects from among all the clinical and experimental disciplines represented at the CIMH. In the ideal case, which happily could be realized in the past within the framework of two important BMBF-funded large-scale projects (Addiction Research Network, Network of Competence “Dementias”), such cooperation is implemented in such a way that in a corresponding research collaboration an own cross-sectional project for the area of biometry / biostatistics was installed and functioned as a temporary extension of the Department. Cooperatative research is supplemented by self-initiated research on statistical methods. As proven by relevant publications in international specialist journals and series of monographs, the Department regularly publishes contributions that develop innovative, improved solutions to biostatistical problems of high relevance for real applications. A major focus of these more theoretical research activities are  statistical methods for the planning and confirmatory analysis of equivalence and noninferiority studies. The achievements attained in this area form the basis of the monograph “Testing Statistical Hypotheses of Equivalence and Noninferiority” published by Chapman & Hall/CRC in 2010. The first edition of this book was nominated by the American Statistical Association as one of the “Top Five Books for Statisticians” of the year 2003.

Other topics are the construction of powerful nonrandomized tests of hypotheses about parameters of discrete distributions, procedures for the planning and evaluation of reference-value studies in medical diagnostics, particularly in the case of dependence of normal values on age or other covariates, methods of testing for goodness rather than lack of fit of statistical models to empirical data, and the objective Bayesian construction of tests satisfying basic frequentist criteria.

Also contributed were solutions to specific problems regularly encountered in the analysis of genome-wide association studies. Notable examples of that kind are testing for compatibility of the distribution of SNPs with Hardy-Weinberg’s law,  assessing associations between SNPs using directly observed joint distributions of genotypes, and the evaluation of the relative merits of Cochran-Armitage’s test for trend as compared with logistic regression in the analysis of genetic association studies.

The department of Biostatistics of the CIMH provides also regularly input and expertise to various boards and agencies within the healthcare and drug regulation systems of the country. Currently,

the (interim) head is a member of  the Expert Commission E of the German Federal Institute for Drugs and Medical Devices (BfArM), as well as the Expert Commission “Off-Label Use in Neurology and Psychiatry” of the BfArM.

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