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RG Longitudinal and Intervention Research


Head of the Research Group

apl. Prof. Dr. Christine Kühner

Phone: +49 621 1703-6057


D 6, 5

Mailing address: J 5, 68159 Mannheim


The RG focuses on cognitive, neurobiological and psychosocial risk factors for the onset and course of mental disorders, particularly depression, experimental psychotherapy and the development of psychodiagnostic tools. Research methods include longitudinal surveys, experimental laboratory and field studies, electronical ambulatory assessment (AA) and, in cooperation with other CIMH groups, functional magnetic resonance imaging (fMRI). In a longitudinal DFG project (2002-2010) we investigated rumination as a cognitive vulnerability factor for depression and related pathomechanisms such as genetic factors and HPA axis functioning, and on distraction and mindfulness as protective modes of attention focusing. In a DFG-funded cooperation project with the Institute of Neuropsychology and Clinical Psychology (SFB 636, 2004 – 2015) we investigate altered associative learning and reward processing in major depression and their neural and behavioural correlates. A further DFG-funded cooperation project with the Department of Clinical Psychology (2010 – 2016) combines electronic AA with fMRI to investigate effects of ruminative and mindful attention focusing on mood and cortisol activity in daily life, and their neural correlates. Present work in this study includes the investigation of possible mechanisms through which short mindfulness-based interventions could exert their positive effects on relapse prevention in depression. The head of the RG is also involved in the development and update of the S3/National Disease Management Guideline Unipolar Depression.

Our RG has internal collaborations with the Institute of Neuropsychology and Clinical Psychology, the Departments of Clinical Psychology, Genetic Epidemiology in Psychiatry and Gerontopsychiatry, and the WG Animal Models in Psychiatry. External collaborations are established with the Universities of Ghent (Dep. of Experimental Clinical and Health Psychology; AA-based rumination measurement), Lausanne (Dep. of Psychiatry; depression, HPA axis, and cardiovascular diseases), Mainz (Dep. of Clinical Psychology and Neuropsychology; cognitive models of depression), and Zurich (Institute of Psychology; psychodiagnostic scales), and with the Karlsruhe Institute of Technology (KIT, Dep. of Applied Psychology, AA).

Zentralinstitut für Seelische Gesundheit (ZI) - https://www.zi-mannheim.de