RG Systems Neurophysiology Group
Phone: +49 621 1703-2341
Therapy Building, 7th Floor, Ward 7 a
Our research group was founded at the CIMH in 2010 within the framework of the Bernstein Center for Computational Neuroscience. First we started establishing a at that time non-existing in-vivo electrophysiology. Meanwhile we have intense collaborations with the groups of Professor Durstewitz and Dr. Kelsch within the CIMH, and beyond with groups from the University of California in Los Angeles and with the Center of Advanced European Studies and Research (CAESAR) in Bonn.
We are interested in higher cognitive processes relevant for psychiatry. Experimental research in this area in our view requires studying intact brains in life animals. For this purpose we record membrane potentials, action potentials and field potentials from single neurons in cortex and hippocampus of rats and mice, and try to link the single neurons’ activity to what the sub-network is doing at large under specific circumstances or tasks. For instance we are recording information flow between neocortex, entorhinal cortex, and hippocampus on the electrophysiological and anatomical level, and influence it pharmacologically. The observed mechanisms play central roles in memory formation, and forgetting, and promise to constitute entry points for psychiatrically relevant therapeutic intervention. In another field we are trying to identify electrophysiological correlates for abnormalities in e.g. genetic animal models of psychiatric disease.
We reckon that for the understanding of complex brain function and for targeted experimentation we need preferably biophysical computational models of neuronal networks. For this purpose we closely collaborate with Dr. Durstewitz and his staff. The aim is to derive specific predictions from models of neuronal network function, and test them experimentally, in order to come to a truly mechanistic understanding of network function.
Zentralinstitut für Seelische Gesundheit (ZI) - https://www.zi-mannheim.de