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Publikationen: Psychopharmakologie

Baron J, Bilbao A, Hörtnagl H, Birnbaumer L, Leixner S, Spanagel R, Ahnert-Hilger G, Brunk I. Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system. J Neurochem. 2018 146(4):374-389. Epub 2018 May 10.
Baur K, Hach A, Bernardi RE, Spanagel R, Bading H, Bengtson CP. c-Fos marking of identified midbrain neurons coactive after nicotine administration in-vivo. J Comp Neurol. 2018 526(13):2019-2031.
Bazov I, Sarkisyan D, Kononenko O, Watanabe H, Yakovleva T, Hansson AC, Sommer WH, Spanagel R, Bakalkin G. Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics. Mol Neurobiol. 2018 55(8):7049-7061. Epub 2018 Jan 30.
Bilbao A, Falfán-Melgoza C, Leixner S, Becker R, Singaravelu SK, Sack MS, Sartorius A, Spanagel R, Weber-Fahr W. Longitudinal Structural and Functional Brain Network Alterations in a Mouse Model of Neuropathic Pain. Neuroscience. 2018 387:104-115. Epub 2018 Apr 22.
Broccoli L, Uhrig S, von Jonquieres G, Schönig K, Bartsch D, Justice NJ, Spanagel R, Sommer WH, Klugmann M, Hansson AC. Targeted overexpression of CRH receptor subtype 1 in central amygdala neurons: effect on alcohol-seeking behavior. Psychopharmacology (Berl). 2018 235(6):1821-1833. Epub 2018 Apr 26.
Cannella N, Cosa-Linan A, Büchler E, Falfán-Melgoza C, Weber-Fahr W, Spanagel R. In vivo structural imaging in rats reveals neuroanatomical correlates of behavioral sub-dimensions of cocaine addiction. Addict Biol. 2018 23(1):182-195. Epub 2017 Feb 23.
Cannella N, Oliveira A, Hemstedt TJ, Lissek T, Buechler E, Bading H, Spanagel R. Dnmt3a2 in the nucleus accumbens shell is required for reinstatement of cocaine seeking. J Neurosci. 2018 38(34):7516-7528. Epub 2018 Jul 20.
Clemm von Hohenberg C, Weber-Fahr W, Lebhardt P., Ravi N, Braun U, Gass N, Becker R, Sack MS, Cosa Linan A, Gerchen MF, Reinwald JR, Oettl LL, Meyer-Lindenberg A, Vollmayr B, Kelsch W, Sartorius A. Lateral habenula perturbation reduces default-mode network connectivity in a rat model of depression. Transl Psychiatry. 2018 8(1):68.
Filipovic D, Stanisavljević A, Jasnić N, Bernardi RE, Inta D, Perić I, Gass P. Chronic Treatment with Fluoxetine or Clozapine of Socially Isolated Rats Prevents Subsector-Specific Reduction of Parvalbumin Immunoreactive Cells in the Hippocampus. Neuroscience. 2018 371:384-394. Epub 2017 Dec 21.
Gass N, Becker R, Sack MS, Schwarz AJ, Reinwald J, Cosa-Linan A, Zheng L, von Hohenberg CC, Inta D, Meyer-Lindenberg A, Weber-Fahr W, Gass P, Sartorius A. Antagonism at the NR2B subunit of NMDA receptors induces increased connectivity of the prefrontal and subcortical regions regulating reward behavior. Psychopharmacology (Berl). 2018 235(4):1055-1068. Epub 2018 Jan 5.
Gerchen MF, Kirsch M, Bahs N, Halli P, Gerhardt S, Schäfer A, Sommer WH, Kiefer F, Kirsch P. The SyBil-AA real-time fMRI neurofeedback study: protocol of a single-blind randomized controlled trial in alcohol use disorder. BMC Psychiatry. 2018 18(1):12.
Gonzalez DA, Jia T, Pinzón JH, Acevedo SF, Ojelade SA, Xu B, Tay N, Desrivieres S, Hernandez JL, Banaschewski T, Büchel C, Bokde ALW, Conrod PJ, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Martinot JL, Paus T, Smolka MN, IMAGEN Consortium , Rodan AR, Schumann G, Rietschel M, Spanagel R, Nees F, Fauth-Bühler M, Millenet S, Grimmer Y, Rothenfluh A. The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans. Mol Psychiatry. 2018 23(3):621-628. Epub 2017 Jun 13.
Hansson AC, Gründer G, Hirth N, Noori HR, Spanagel R, Sommer WH. Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies. Neurosci Biobehav Rev. 2018 Sep 19. [Epub ahead of print]
Hansson AC, Koopmann A, Uhrig S, Bühler S, Domi E, Kiessling E, Ciccocioppo R, Froemke RC, Grinevich V, Kiefer F, Sommer WH, Vollstädt-Klein S, Spanagel R. Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol Dependent Rats and Humans. Neuropsychopharmacology. 2018 43(6):1235-1246. Epub 2017 Nov 1.
Hirjak D, Meyer-Lindenberg A, Fritze S, Sambataro F, Kubera KM, Wolf RC. Motor dysfunction as research domain across bipolar, obsessive-compulsive and neurodevelopmental disorders. Neurosci Biobehav Rev. 2018 95:315-335. Epub 2018 Sep 17.
Leweke FM, Mueller JK, Lange B, Fritze S, Topor CE, Koethe D, Rohleder C. Role of the Endocannabinoid System in the Pathophysiology of Schizophrenia: Implications for Pharmacological Intervention. CNS Drugs. 2018 32(7):605-619.
Mielenz D, Reichel M, Jia T, Quinlan EB, Stöckl T, Mettang M, Zilske D, Kirmizi-Alsan E, Schönberger P, Praetner M, Huber SE, Amato D, Schwarz M, Purohit P, Brachs S, Spranger J, Heß A, Büttner C, Ekici AB, Perez-Branguli F, Winner B, Rauschenberger V, Banaschewski T, Bokde AL, Büchel C, Conrod PJ, Desrivieres S, Flor H, Frouin V, Gallinat J, Garavan H, Gowland P, Heinz A, Martinot JL, Lemaitre H, Nees F, Paus T, Smolka MN, IMAGEN Consortium , Schambony A, Bäuerle T, Eulenburg V, Alzheimer C, Lourdusamy A, Schumann G, Mann K, Rietschel M, Spanagel R, Fauth-Bühler M, Millenet S, Grimmer Y, Muller CP. EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction. Mol Psychiatry. 2018 23(5):1303-1317. Epub 2017 Apr 11.
Noori HR, Mervin LH, Bokharaie V, Durmus Ö, Egenrieder L, Fritze S, Gruhlke B, Reinhardt G, Schabel H, Staudenmaier S, Logothetis NK, Bender A, Spanagel R. Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs. Nat Commun. 2018 9(1):4699.
Noori HR, Mücksch C, Vengeliene V, Schönig K, Takahashi TT, Mukhtasimova N, Bagher Oskouei M, Mosqueira M, Bartsch D, Fink R, Urbassek HM, Spanagel R, Sine SM. Alcohol reduces muscle fatigue through atomistic interactions with nicotinic receptors. Commun Biol. 2018 1:159.
Pfarr S, Schaaf L, Reinert JK, Paul E, Herrmannsdörfer F, Roßmanith M, Kuner T, Hansson AC, Spanagel R, Körber C, Sommer WH. Choice for drug or natural reward engages largely overlapping neuronal ensembles in the infralimbic prefrontal cortex. J Neurosci. 2018 38(14):3507-3519. Epub 2018 Feb 24.
Pätz T, Frischknecht U, Dinter C, Reinhard I, Mann KF, Kiefer F, Weber T. Tabakentwöhnung mit kognitiv-behavioraler Gruppentherapie während einer 3-wöchigen qualifizierten Alkoholentzugsbehandlung. Verhaltenstherapie. 2018 28:230-237.
Reinwald JR, Becker R, Mallien A, Falfán-Melgoza C, Sack MS, Clemm von Hohenberg C, Braun U, Cosa Linan A, Gass N, Vasilescu AN, Tollens F, Lebhardt P., Pfeiffer N, Inta D, Meyer-Lindenberg A, Gass P, Sartorius A, Weber-Fahr W. Neural Mechanisms of Early-Life Social Stress as a Developmental Risk Factor for Severe Psychiatric Disorders. Biol Psychiatry. 2018 84(2):116-128. Epub 2017 Dec 28.
Rohleder C, Koethe D, Fritze S, Topor CE, Leweke FM, Hirjak D. Neural correlates of binocular depth inversion illusion in antipsychotic-naïve first-episode schizophrenia patients. Eur Arch Psychiatry Clin Neurosci. 2018 Mar 19. [Epub ahead of print]
Ruggeri B, Macare C, Stopponi S, Jia T, Carvalho FM, Robert G, Banaschewski T, Bokde AL, Bromberg U, Büchel C, Cattrell A, Conrod PJ, Desrivieres S, Flor H, Frouin V, Gallinat J, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Martinot MP, Nees F, Papadopoulos-Orfanos D, Paus T, Poustka L, Smolka MN, Vetter NC, Walter H, Whelan R, Sommer WH, Bakalkin G, Ciccocioppo R, Schumann G, IMAGEN consortium . Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents. J Child Psychol Psychiatry. 2018 59(6):650-658. Epub 2017 Dec 2.
Spanagel R. Alterations of the Biological Clock May Contribute to the Emergence of Mental Disorders During Adolescence. Biol Psychiatry. 2018 83(12):978-980.
Spanagel R. Aberrant choice behavior in alcoholism. Science. 2018 360(6395):1298-1299.
Streit F, Treutlein J, Frischknecht U, Hermann D, Mann K, Kiefer F, Sack MS, Hall ASM, Frank J, Witt SH, Foo JC, Degenhardt F, Heilmann-Heimbach S, Nöthen MM, Sommer WH, Spanagel R, Rietschel M, Ende G. Glutamate concentration in the anterior cingulate cortex in alcohol dependence: association with alcohol withdrawal and exploration of contribution from glutamatergic candidate genes. Psychiatr Genet. 2018 28(5):94-95. Epub 2018 Jul 5.
Vengeliene V, Rossmanith M, Takahashi TT, Alberati D, Behl B, Bespalov A, Spanagel R. Targeting Glycine Reuptake in Alcohol Seeking and Relapse. J Pharmacol Exp Ther. 2018 :202-211. Epub 2018 Jan 24.
Vengeliene V, Takahashi TT, Dravolina OA, Belozertseva I, Zvartau E, Bespalov AY, Spanagel R. Efficacy and side effects of baclofen and the novel GABA receptor positive allosteric modulator CMPPE in animal models for alcohol and cocaine addiction. Psychopharmacology (Berl). 2018 235(7):1955-1965. Epub 2018 Apr 12.
van den Brink W, Addolorato G, Aubin HJ, Benyamina A, Caputo F, Dematteis M, Gual A, Lesch OM, Mann K, Maremmani I, Nutt D, Paille F, Perney P, Rehm J, Reynaud M, Simon N, Söderpalm B, Sommer WH, Walter H, Spanagel R. Efficacy and safety of sodium oxybate in alcohol-dependent patients with a very high drinking risk level. Addict Biol. 2018 23(4):969-986.


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