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Publikationen: Translationale Psychoseforschung (TRiP)

Amess B, Kluge W, Schwarz E, Haenisch F, Alsaif M, Yolken RH, Leweke FM, Guest PC, Bahn S. Application of meta-analysis methods for identifying proteomic expression level differences. Proteomics. 2013 13(14):2072-6. Epub 2013 Apr 14.
Anderson-Schmidt H, Adler L, Aly C, Anghelescu IG, Bauer M, Baumgärtner J, Becker J, Bianco R, Becker T, Bitter C, Bönsch D, Buckow K, Budde M, Bührig M, Deckert J, Demiroglu SY, Dietrich D, Dümpelmann M, Engelhardt U, Fallgatter AJ, Feldhaus D, Figge C, Folkerts H, Franz M, Gade K, Gaebel W, Grabe HJ, Gruber O, Gullatz V, Gusky L, Heilbronner U, Helbing K, Hegerl U, Heinz A, Hensch T, Hiemke C, Jäger M, Jahn-Brodmann A, Juckel G, Kandulski F, Kaschka WP, Kircher T, Koller M, Konrad C, Kornhuber J, Krause M, Krug A, Lee M, Leweke M, Lieb K, Mammes M, Meyer-Lindenberg A, Mühlbacher M, Müller MJ, Nieratschker V, Nierste B, Ohle J, Pfennig A, Pieper M, Quade M, Reich-Erkelenz D, Reif A, Reitt M, Reininghaus B, Reininghaus EZ, Riemenschneider M, Rienhoff O, Roser P, Rujescu D, Schennach R, Scherk H, Schmauss M, Schneider F, Schosser A, Schott BH, Schwab SG, Schwanke J, Skrowny D, Spitzer C, Stierl S, Stöckel J, Stübner S, Thiel A, Volz HP, von Hagen M, Walter H, Witt SH, Wobrock T, Zielasek J, Zimmermann J, Zitzelsberger A, Maier W, Falkai PG, Rietschel M, Schulze TG. The "DGPPN-Cohort": a national collaboration initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for establishing a large-scale cohort of psychiatric patients. Eur Arch Psychiatry Clin Neurosci. 2013 263(8):695-701. Epub 2013 Apr 3.
Bray NJ, Leweke FM, Kapur S, Meyer-Lindenberg A. The neurobiology of schizophrenia: new leads and avenues for treatment. Curr Opin Neurobiol. 2010 20(6):810-5. Epub 2010 Oct 8.
Bumb JM, Enning F, Leweke FM. Repurposed drugs for the treatment of schizophrenia and bipolar disorders. Curr Top Med Chem. 2013 13(18):2364-85.
Bumb JM, Schilling C, Enning F, Haddad L, Paul F, Lederbogen F, Deuschle M, Schredl M, Nolte I. Pineal gland volume in primary insomnia and healthy controls: a magnetic resonance imaging study. J Sleep Res. 2014 23(3):274-80. Epub 2014 Jan 24.
Ceccarini J, De Hert M, van Winkel R, Peuskens J, Bormans G, Kranaster L, Enning F, Koethe D, Leweke FM, Van Laere K. Increased ventral striatal CB1 receptor binding is related to negative symptoms in drug-free patients with schizophrenia. Neuroimage. 2013 79:304-312. Epub 2013 Apr 25.
Coughlin JM, Ishizuka K, Kano SI, Edwards JA, Seifuddin FT, Shimano MA, Daley EL, Zandi PP, Leweke FM, Cascella NG, Pomper MG, Yolken RH, Sawa A. Marked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia. Mol Psychiatry. 2013 18(1):10-1.
Deuschle M, Schilling C, Leweke FM, Enning F, Pollmächer T, Esselmann H, Wiltfang J, Frölich L, Heuser I. Hypocretin in cerebrospinal fluid is positively correlated with Tau and pTau. Neurosci Lett. 2014 21:41-5. Epub 2013 Dec 25.
Englisch S, Eer A, Enning F, Hohmann S, Schanz H, Zink M. Augmentation With Pregabalin in Schizophrenia. J Clin Psychopharmacol. 2010 30(4):437-40. Epub 2010 May 29.
Englisch S, Enning F, Grosshans M, Marquardt L, Waltereit R, Zink M. Quetiapine Combined With Amisulpride in Schizophrenic Patients With Insufficient Responses to Quetiapine Monotherapy. Clin Neuropharmacol. 2010 33(5):227-9. Epub 2010 Sep 6.
European Network of National Networks studying Gene-Environment Interactions in Schizophrenia (EU-GEI) , van Os J, Rutten BP, Myin-Germeys I, Delespaul P, Viechtbauer W, van Zelst C, Bruggeman R, Reininghaus U, Morgan C, Murray RM, Di Forti M, McGuire P, Valmaggia LR, Kempton MJ, Gayer-Anderson C, Hubbard K, Beards S, Stilo SA, Onyejiaka A, Bourque F, Modinos G, Tognin S, Calem M, O'Donovan MC, Owen MJ, Holmans P, Williams N, Craddock N, Richards A, Humphreys I, Meyer-Lindenberg A, Leweke FM, Tost H, Akdeniz C, Rohleder C, Bumb JM, Schwarz E, Alptekin K, Üçok A, Saka MC, Atbaşoğlu EC, Gülöksüz S, Gumus-Akay G, Cihan B, Karadağ H, Soygür H, Cankurtaran EŞ, Ulusoy S, Akdede B, Binbay T, Ayer A, Noyan H, Karadayı G, Akturan E, Ulaş H, Arango C, Parellada M, Bernardo M, Sanjuan J, Bobes J, Arrojo M, Santos JL, Cuadrado P, Rodríguez Solano JJ, Carracedo A, García Bernardo E, Roldán L, López G, Cabrera B, Cruz S, Díaz Mesa EM, Pouso M, Jiménez E, Sánchez T, Rapado M, González E, Martínez C, Sánchez E, Olmeda MS, de Haan L, Velthorst E, van der Gaag M, Selten JP, van Dam D, van der Ven E, van der Meer F, Messchaert E, Kraan T, Burger N, Leboyer M, Szoke A, Schürhoff F, Llorca PM, Jamain S, Tortelli A, Frijda F, Vilain J, Galliot AM, Baudin G, Ferchiou A, Richard JR, Bulzacka E, Charpeaud T, Tronche AM, De Hert M, van Winkel R, Decoster J, Derom C, Thiery E, Stefanis NC, Sachs G, Aschauer H, Lasser I, Winklbaur B, Schlögelhofer M, Riecher-Rössler A, Borgwardt S, Walter A, Harrisberger F, Smieskova R, Rapp C, Ittig S, Soguel-dit-Piquard F, Studerus E, Klosterkötter J, Ruhrmann S, Paruch J, Julkowski D, Hilboll D, Sham PC, Cherny SS, Chen EY, Campbell DD, Li M, Romeo-Casabona CM, Emaldi Cirión A, Urruela Mora A, Jones P, Kirkbride J, Cannon M, Rujescu D, Tarricone I, Berardi D, Bonora E, Seri M, Marcacci T, Chiri L, Chierzi F, Storbini V, Braca M, Minenna MG, Donegani I, Fioritti A, La Barbera D, La Cascia CE, Mulè A, Sideli L, Sartorio R, Ferraro L, Tripoli G, Seminerio F, Marinaro AM, McGorry P, Nelson B, Amminger GP, Pantelis C, Menezes PR, Del-Ben CM, Gallo Tenan SH, Shuhama R, Ruggeri M, Tosato S, Lasalvia A, Bonetto C, Ira E, Nordentoft M, Krebs MO, Barrantes-Vidal N, Cristóbal P, Kwapil TR, Brietzke E, Bressan RA, Gadelha A, Maric NP, Andric S, Mihaljevic M, Mirjanic T. Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations. Schizophr Bull. 2014 40(4):729-36.
Guest PC, Schwarz E, Krishnamurthy D, Harris LW, Leweke FM, Rothermundt M, van Beveren NJ, Spain M, Barnes A, Steiner J, Rahmoune H, Bahn S. Altered levels of circulating insulin and other neuroendocrine hormones associated with the onset of schizophrenia. Psychoneuroendocrinology. 2011 36(7):1092-6. Epub 2011 Jan 20.
Guest PC, Wang L, Harris LW, Burling K, Levin Y, Ernst A, Wayland MT, Umrania Y, Herberth M, Koethe D, van Beveren JM, Rothermundt M, McAllister G, Leweke FM, Steiner J, Bahn S. Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naïve schizophrenia patients. Mol Psychiatry. 2010 15(2):118-9.
Hayes LN, Severance EG, Leek JT, Gressitt KL, Rohleder C, Coughlin JM, Leweke FM, Yolken RH, Sawa A. Inflammatory molecular signature associated with infectious agents in psychosis. Schizophr Bull. 2014 40(5):963-72.
Herberth M, Koethe D, Cheng TM, Krzyszton ND, Schoeffmann S, Guest PC, Rahmoune H, Harris LW, Kranaster L, Leweke FM, Bahn S. Impaired glycolytic response in peripheral blood mononuclear cells of first-onset antipsychotic-naive schizophrenia patients. Mol Psychiatry. 2011 16(8):848-59. Epub 2010 Jun 29.
Herberth M, Koethe D, Levin Y, Schwarz E, Krzyszton ND, Schoeffmann S, Ruh H, Rahmoune H, Kranaster L, Schoenborn T, Leweke MF, Guest PC, Bahn S. Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival. Proteomics. 2011 11(1):94-105.
Herberth M, Koethe D, Levin Y, Schwarz E, Krzyszton ND, Schoeffmann S, Ruh H, Rahmoune H, Kranaster L, Schoenborn T, Leweke MF, Guest PC, Bahn S. Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival. Proteomics Clin Appl. 2011 5(7-8):468.
Herberth M, Krzyszton DN, Koethe D, Craddock MR, Bulger E, Schwarz E, Guest P, Leweke FM, Bahn S. Differential effects on T-cell function following exposure to serum from schizophrenia smokers. Mol Psychiatry. 2010 15(4):364-71. Epub 2008 Nov 11.
Herberth M, Krzyszton DN, Koethe D, Craddock MR, Bulger E, Schwarz E, Guest P, Leweke FM, Bahn S. Differential effects on T-cell function following exposure to serum from schizophrenia smokers. Mol Psychiatry. 2009 14(12):1145.
Herberth M, Rahmoune H, Schwarz E, Koethe D, Harris LW, Kranaster L, Witt SH, Spain M, Barnes A, Schmolz M, Leweke MF, Guest PC, Bahn S. Identification of a molecular profile associated with immune status in first onset schizophrenia patients. Clin Schizophr Relat Psychoses. 2014 7(4):207-15. Epub 2013 Feb 8.
Hoyer C, Kranaster L, Leweke FM, Klosterkötter J, Meyer-Lindenberg A, Koethe D. Familial Differential Treatment Response in Schizophrenia - Lessons From a Case of Three Affected Siblings. Pharmacopsychiatry. 2010 43(5):196-7. Epub 2010 Feb 26.
Jaros JA, Guest PC, Ramoune H, Rothermundt M, Leweke FM, Martins-de-Souza D, Bahn S. Clinical use of phosphorylated proteins in blood serum analysed by immobilised metal ion affinity chromatography and mass spectrometry. J Proteomics. 2012 76(Spec No):36-42. Epub 2012 Feb 22.
Jaros JA, Martins-de-Souza D, Rahmoune H, Rothermundt M, Leweke FM, Guest PC, Bahn S. Protein phosphorylation patterns in serum from schizophrenia patients and healthy controls. J Proteomics. 2012 76(Spec No):43-55. Epub 2012 May 26.
Jaros JA, Martins-de-Souza D, Rahmoune H, Schwarz E, Leweke FM, Guest PC, Bahn S. Differential phosphorylation of serum proteins reflecting inflammatory changes in schizophrenia patients. Eur Arch Psychiatry Clin Neurosci. 2012 262(5):453-5. Epub 2011 Dec 15.
Klugmann M, Klippenstein V, Leweke FM, Spanagel R, Schneider M. Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels. Int J Neuropsychopharmacol. 2011 14(4):505-17. Epub 2011 Jan 7.
Koethe D, Giuffrida A, Schreiber D, Hellmich M, Schultze-Lutter F, Ruhrmann S, Klosterkötter J, Piomelli D, Leweke FM. Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis. Br J Psychiatry. 2009 194(4):371-2.
Koethe D, Hoyer C, Leweke FM. The endocannabinoid system as a target for modelling psychosis. Psychopharmacology (Berl). 2009 206(4):551-61. Epub 2009 Jun 16.
Koethe D, Kranaster L, Hoyer C, Gross S, Neatby MA, Schultze-Lutter F, Ruhrmann S, Klosterkötter J, Hellmich M, Leweke FM. Binocular depth inversion as a paradigm of reduced visual information processing in prodromal state, antipsychotic-naïve and treated schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2009 259(4):195-202.
Koethe D, Schreiber D, Giuffrida A, Mauss C, Faulhaber J, Heydenreich B, Hellmich M, Graf R, Klosterkötter J, Piomelli D, Leweke FM. Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid. J Neural Transm. 2009 116(3):301-305. Epub 2009 Jan 22.
Koutroukides TA, Guest PC, Leweke FM, Bailey DM, Rahmoune H, Bahn S, Martins-de-Souza D. Characterization of the human serum depletome by label-free shotgun proteomics. J Sep Sci. 2011 34(13):1621-6. Epub 2011 Jun 3.
Kranaster L, Koethe D, Hoyer C, Meyer-Lindenberg A, Leweke FM. Cerebrospinal fluid diagnostics in first-episode schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2011 261(7):529-30. Epub 2011 Feb 6..
Krishnamurthy D, Harris LW, Levin Y, Koutroukides TA, Rahmoune H, Pietsch S, Vanattou-Saifoudine N, Leweke FM, Guest PC, Bahn S. Metabolic, hormonal and stress-related molecular changes in post-mortem pituitary glands from schizophrenia subjects. World J Biol Psychiatry. 2013 14(7):478-89. Epub 2012 Jan 17.
Levin Y, Wang L, Schwarz E, Koethe D, Leweke FM, Bahn S. Global proteomic profiling reveals altered proteomic signature in schizophrenia serum. Mol Psychiatry. 2010 15(11):1088-100. Epub 2009 Jun 23.
Leweke FM. Anandamide dysfunction in prodromal and established psychosis. Curr Pharm Des. 2012 18(32):5188-93. Epub 2012 Jun 7.
Leweke FM. Schizophrenia. Curr Top Behav Neurosci. 2009 1:387-96.
Leweke FM, Odorfer TM, Bumb JM. Medical needs in the treatment of psychotic disorders. Handb Exp Pharmacol. 2012 (212):165-85.
Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C, Klosterkötter J, Hellmich M, Koethe D. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl Psychiatry. 2012 2:e94.
Leweke FM, Schneider M. Chronic pubertal cannabinoid treatment as a behavioural model for aspects of schizophrenia: effects of the atypical antipsychotic quetiapine. Int J Neuropsychopharmacol. 2011 14(1):43-51. Epub 2010 Aug 3.
Morgan CJ, Page E, Schaefer C, Chatten K, Manocha A, Gulati S, Curran HV, Brandner B, Leweke FM. Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms. Br J Psychiatry. 2013 202(5):381-2.
Muhl D, Kathmann M, Hoyer C, Kranaster L, Hellmich M, Gerth CW, Faulhaber J, Schlicker E, Leweke FM. Increased CB2 mRNA and anandamide in human blood after cessation of cannabis abuse. Naunyn Schmiedebergs Arch Pharmacol. 2014 387(7):691-5.
Ramsey JM, Schwarz E, Guest PC, van Beveren NJ, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Bahn S. Distinct molecular phenotypes in male and female schizophrenia patients. PLoS ONE. 2013 8(11):e78729.
Ramsey JM, Schwarz E, Guest PC, van Beveren NJ, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Ruta L, Baron-Cohen S, Bahn S. Molecular sex differences in human serum. PLoS ONE. 2012 7(12):e51504.
Rivolta D, Castellanos NP, Stawowsky C, Helbling S, Wibral M, Grützner C, Koethe D, Birkner K, Kranaster L, Enning F, Singer W, Leweke FM, Uhlhaas PJ. Source-reconstruction of event-related fields reveals hyperfunction and hypofunction of cortical circuits in antipsychotic-naive, first-episode schizophrenia patients during Mooney face processing. J Neurosci. 2014 34(17):5909-17.
Rohleder C, Jung F, Mertgens H, Wiedermann D, Sué M, Neumaier B, Graf R, Leweke FM, Endepols H. Neural correlates of sensorimotor gating: a metabolic positron emission tomography study in awake rats. Front Behav Neurosci. 2014 8:178.
Schaefer C, Enning F, Mueller JK, Bumb JM, Rohleder C, Odorfer TM, Klosterkötter J, Hellmich M, Koethe D, Schmahl C, Bohus M, Leweke FM. Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders. Eur Arch Psychiatry Clin Neurosci. 2014 264(5):459-63. Epub 2013 Nov 20.
Schwarz E, Guest PC, Rahmoune H, Harris LW, Wang L, Leweke FM, Rothermundt M, Bogerts B, Koethe D, Kranaster L, Ohrmann P, Suslow T, McAllister G, Spain M, Barnes A, van Beveren NJ, Baron-Cohen S, Steiner J, Torrey FE, Yolken RH, Bahn S. Identification of a biological signature for schizophrenia in serum. Mol Psychiatry. 2012 17(5):494-502. Epub 2011 Apr 12..
Schwarz E, Izmailov R, Spain M, Barnes A, Mapes JP, Guest PC, Rahmoune H, Pietsch S, Leweke FM, Rothermundt M, Steiner J, Koethe D, Kranaster L, Ohrmann P, Suslow T, Levin Y, Bogerts B, van Beveren NJ, McAllister G, Weber N, Niebuhr D, Cowan D, Yolken RH, Bahn S. Validation of a blood-based laboratory test to aid in the confirmation of a diagnosis of schizophrenia. Biomark Insights. 2010 5:39-47.
Schwarz E, Leweke FM, Bahn S, Liò P. Clinical bioinformatics for complex disorders: a schizophrenia case study. BMC Bioinformatics. 2009 10 Suppl 12:S6.
Schwarz E, Whitfield P, Nahnsen S, Wang L, Major H, Leweke FM, Koethe D, Liò P, Bahn S. Alterations of primary fatty acid amides in serum of patients with severe mental illness. Front Biosci (Elite Ed). 2011 3:308-14.
Schwarz E, van Beveren NJ, Ramsey J, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Guest PC, Bahn S. Identification of Subgroups of Schizophrenia Patients With Changes in Either Immune or Growth Factor and Hormonal Pathways. Schizophr Bull. 2014 40(4):787-95. Epub 2013 Aug 9.
Severance EG, Alaedini A, Yang S, Halling M, Gressitt KL, Stallings CR, Origoni AE, Vaughan C, Khushalani S, Leweke FM, Dickerson FB, Yolken RH. Gastrointestinal inflammation and associated immune activation in schizophrenia. Schizophr Res. 2012 138(1):48-53. Epub 2012 Mar 24..
Severance EG, Gressitt KL, Stallings CR, Origoni AE, Khushalani S, Leweke FM, Dickerson FB, Yolken RH. Discordant patterns of bacterial translocation markers and implications for innate immune imbalances in schizophrenia. Schizophr Res. 2013 148(1-3):130-7. Epub 2013 Jun 6.
Stanta JL, Saldova R, Struwe WB, Byrne JC, Leweke FM, Rothermund M, Rahnoune H, Levin Y, Guest P, Bahn S, Rudd PM. Identification of N-glycosylation changes in the CSF and serum in patients with schizophrenia. J Proteome Res. 2010 9(9):4476-89.
Sun L, Castellanos N, Grützner C, Koethe D, Rivolta D, Wibral M, Kranaster L, Singer W, Leweke MF, Uhlhaas PJ. Evidence for dysregulated high-frequency oscillations during sensory processing in medication-naïve, first episode schizophrenia. Schizophr Res. 2013 150(2-3):519-25. Epub 2013 Sep 7.
Telford JE, Bones J, McManus C, Saldova R, Manning G, Doherty M, Leweke FM, Rothermundt M, Guest PC, Rahmoune H, Bahn S, Rudd PM. Anti-psychotic treatment of acute paranoid schizophrenia patients with olanzapine results in altered glycosylation of serum glycoproteins. J Proteome Res. 2012 11(7):3743-52. Epub 2012 May 29.


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