Informationen: Theoretische Neurowissenschaften
Highly data-driven models of neural computation and dynamics
To gain insight into the physiological, neuro-dynamical, and neuro-computational principles and mechanisms underlying behavior and cognition, we develop mathematical models of single neurons and networks. 'Highly data-driven' in this context means that parameters of these models are directly estimated from in-vitro and/or in-vivo electrophysiological data, often in statistically principled ways (e.g. maximum likelihood). Our focus is on brain structures like the prefrontal cortex or hippocampus which are involved in higher cognitive functions, such as rule learning, working memory, or decision making.
Application in psychiatric contexts
We use such models in an attempt to understand not only the healthy state, but also which aspects of networks dynamics may go aberrant in psychiatric conditions, which implications this may have for computational function and behavior, and how potentially 'healthy network dynamics' could be restored. We do this on the basis of neural network models estimated from relevant genetic and pharmacological animal models.
Statistical analysis of neural coding and dynamics
Recent advances in multiple single-unit recordings and neuroimaging enable to readdress some long-standing questions about the neural code, the language of the brain. Having simultaneous recordings from the activity of tens to hundreds of neurons, we develop new statistical tools to mine these data sets for spatio-temporal patterns representing environmental or cognitive events, and for reconstructing from these the underlying network dynamics. These statistical approaches complement our model-based analyses of healthy and aberrant network function.
Illustration of a state space model (left-hand side) for inferring neuronal dynamics (right-hand side) from electrophysiological data. A state space model assumes that observed quantities ('yt'; action potential time points in this example) are generated through not directly observable neural processes ('zt') which follow a specific temporal dynamic, illustrated as a vector ('flow') field on the right hand side. This is an example of how neural models and statistical estimation algorithms can be applied to recover non-directly-observable processes from observed measurements given specific stimulus conditions ('ut'; 'cherry' and 'lemon' in this example), in this case to infer latent brain dynamics for the purpose of diagnosis or prognosis.
Programs & Downloads
- Method for stationarity-segmentation of spike train data
- Analytical Approximation of the Firing Rate of an aEIF Neuron in the Presence of Synaptic Noise
- Fitting the simplified AdEx model to physiological data
- Neural Trajectories Reconstruction Matlab Toolbox 1.5 beta
- Dynamical Basis of Irregular Spiking in NMDA-Driven PFC Neurons
- Self-Organizing Neural Integrator Predicts Interval Times through Climbing Activity
- A detailed data-driven network model of prefrontal cortex reproduces key features of in vivo activity
- Method for cell assembly detection in parallel spike trains
- Github repository for PLRNN MATLAB code (see Durstewitz, D. (2017), PLoS Comput Biol 13)
Zentralinstitut für Seelische Gesundheit (ZI) - https://www.zi-mannheim.de