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Dr. Arthur Lefevre

About me

After a PhD in Lyon (France) where I studied the interaction between oxytocin and serotonin in macaque monkeys, I joined Valery’s lab in September 2017. I am particularly fascinated by the diversity of oxytocin effects on behavior. To investigate how one neuropeptide exert so many functions, I use viral tools to study its effects on social behavior, fear and pain in the prefrontal cortex, paraventricular thalamus and periaqueductal gray matter.

 

In 2022 I joined the lab of Cory Miller (UCSD).


Arthur holds a PhD in Neuroscience, an M.Sc. in Neurobiology and a B.Sc. in „Informatics and cognitive sciences“. He currently works as a postdoc in our team.

Expertise

OptogeneticsViral tracing
NeuroimagingCalcium imaging
Publications in peer reviewed journals since 2006

TOP 5 publications:

  1. Wahis J, Baudon A, Althammer F, Kerspern D, Goyon S, Hagiwara D, Lefevre A, Barteczko L, Boury-Jamot B, Bellanger B, Abatis M, da Silva Gouveia M, Benusiglio D, Eliava M, Rozov A, Weinsanto I, Knobloch-Bollmann HS, Kirchner MK, Roy RK, Wang H, Pertin M, Inquimbert P, Pitzer C, Siemens J, Goumon Y, Boutrel B, Lamy CM, Decosterd I, Chatton JY, Rouach N, Young WS, Stern JE, Poisbeau P, Stoop R, Darbon P, Grinevich V, Charlet A. Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents.Nat Neurosci. 2021 24(4):529-541. Epub 2021 Feb 15.
  2. Tang Y, Benusiglio D, Lefevre A, Hilfiger L, Althammer F, Bludau A, Hagiwara D, Baudon A, Darbon P, Schimmer J, Kirchner MK, Roy RK, Wang S, Eliava M, Wagner S, Oberhuber M, Conzelmann KK, Schwarz M, Stern JE, Leng G, Neumann ID, Charlet A, Grinevich V. Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons.Nat Neurosci. 2020 23(9):1125-1137. Epub 2020 Jul 27.
  3. Thirtamara Rajamani K, Leithead AB, Kim M, Barbier M, Peruggia M, Niblo K, Barteczko L, Lefevre A, Grinevich V, Harony-Nicolas H. Efficiency of cell-type specific and generic promoters in transducing oxytocin neurons and monitoring their neural activity during lactation.Sci Rep. 2021 11(1):22541.
  4. Lefevre A, Benusiglio D, Tang Y, Krabichler Q, Charlet A, Grinevich V. Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors.Front Neural Circuits. 2021 15:688234.
  5. Tang Y, Benusiglio D, Lefevre A, Küppers S, Lapies O, Kerspern D, Charlet A, Grinevich V. Viral vectors for opto-electrode recording and photometry-based imaging of oxytocin neurons in anesthetized and socially interacting rats.STAR Protoc. 2022 3(1):101032.

Zentralinstitut für Seelische Gesundheit (ZI) - https://www.zi-mannheim.de