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Dr. rer. nat. Tobias Buchborn

Psychologist | Research Associate

Department Molecular Neuroimaging

Institute Psychopharmacology

RG Translational Psychopharmacology

Phone: +49 621 1703-6245

e-mail

Laboratory building, room 4.14

Tobias Buchborn graduated in Psychology (Dipl. Psych.) at the Otto-von-Guericke University (OvGU), Magdeburg. In his Diploma thesis, he investigated the behavioural and pharmacodynamic effects of the psychedelic LSD in animal model of depression.

Tobias received his PhD (Dr. rer. nat.) in Neurobiology from the Faculty of Natural Sciences, OvGU. His PhD project was conducted at the Institute of Pharmacology and Toxicology, OvGU, and addressed the behavioural and molecular biological correlates of differential tolerance to psychedelics, with focus on processes of 5-HT2A regulation.

In 2016, Tobias was awarded an Individual MSCA Research Fellowship to join Imperial College, London, Department of Brain Sciences. Here, he investigated the corticodynamics of psychedelic drug action by means of cell-type specific, optogenetic voltage imaging.

Since 2021 Tobias is with the Institute of Psychopharmacology, Central Institute of Mental Health Mannheim, where he uses refined techniques of chemogenetics and fibre photometry to learn about the therapeutic applicability of psychedelic drugs in the treatment of addiction disorders.

Publications in peer reviewed journals since 2006

TOP 5 publications:

  1. Kärtner L, Steinborn MB, Kettner H, Spriggs MJ, Roseman L, Buchborn T, Balaet M, Timmermann C, Erritzoe D, Carhart-Harris RL. Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing.Sci Rep. 2021 11(1):1941.
  2. Spriggs MJ, Giribaldi B, Lyons T, Rosas FE, Kärtner LS, Buchborn T, Douglass HM, Roseman L, Timmermann C, Erritzoe D, Nutt DJ, Carhart-Harris RL. Body mass index (BMI) does not predict responses to psilocybin.J Psychopharmacol. 2023 37(1):107-116.
  3. Buchborn T, Lyons T, Song C, Feilding A, Knöpfel T. The serotonin 2A receptor agonist 25CN-NBOH increases murine heart rate and neck-arterial blood flow in a temperature-dependent manner.J Psychopharmacol. 2020 34(7):786-794.
  4. Buchborn T, Lyons T, Knöpfel T. Tolerance and Tachyphylaxis to Head Twitches Induced by the 5-HT2A Agonist 25CN-NBOH in Mice.Front Pharmacol. 2018 9:17.
  5. Buchborn T, Schröder H, Höllt V, Grecksch G. Repeated lysergic acid diethylamide in an animal model of depression: Normalisation of learning behaviour and hippocampal serotonin 5-HT2 signalling.J Psychopharmacol. 2014 28(6):545-52.

Zentralinstitut für Seelische Gesundheit (ZI) - https://www.zi-mannheim.de