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Dr. rer. nat. Tobias Buchborn

Psychologist | Research Associate

Department Molecular Neuroimaging

Institute Psychopharmacology

RG Translational Psychopharmacology

Phone: +49 621 1703-6245

e-mail

Laboratory building, room 4.14

Tobias Buchborn graduated with a diploma in psychology from the Otto-von-Guericke University (OvGU) in Magdeburg. For his diploma thesis, he investigated the behavioural and pharmacodynamic effects of the psychedelic drug LSD in a depression animal model.
 

Tobias received his PhD in neurobiology (Dr rer nat) from the Faculty of Natural Sciences at OvGU. He conducted his PhD project at the OvGU Institute of Pharmacology and Toxicology, addressing the behavioural and molecular biological correlates of differential tolerance to psychedelics with a focus on 5-HT2A regulation processes.
 

In 2016, Tobias was awarded an Individual MSCA Research Fellowship to join the Department of Brain Sciences at Imperial College London. There, he investigated the corticodynamics of the action of psychedelic drugs by means of cell-type-specific optogenetic voltage imaging.

 

Tobias has been working at the Institute of Psychopharmacology at the Central Institute of Mental Health in Mannheim since 2021. There, he uses advanced chemogenetic and fibre-photometric techniques to study the therapeutic potential of psychedelic drugs for treating addiction disorders.

Publications in peer reviewed journals since 2006

TOP 5 publications:

  1. Kärtner L, Steinborn MB, Kettner H, Spriggs MJ, Roseman L, Buchborn T, Balaet M, Timmermann C, Erritzoe D, Carhart-Harris RL. Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing.Sci Rep. 2021 11(1):1941.
  2. Spriggs MJ, Giribaldi B, Lyons T, Rosas FE, Kärtner LS, Buchborn T, Douglass HM, Roseman L, Timmermann C, Erritzoe D, Nutt DJ, Carhart-Harris RL. Body mass index (BMI) does not predict responses to psilocybin.J Psychopharmacol. 2023 37(1):107-116.
  3. Buchborn T, Lyons T, Song C, Feilding A, Knöpfel T. The serotonin 2A receptor agonist 25CN-NBOH increases murine heart rate and neck-arterial blood flow in a temperature-dependent manner.J Psychopharmacol. 2020 34(7):786-794.
  4. Buchborn T, Lyons T, Knöpfel T. Tolerance and Tachyphylaxis to Head Twitches Induced by the 5-HT2A Agonist 25CN-NBOH in Mice.Front Pharmacol. 2018 9:17.
  5. Buchborn T, Schröder H, Höllt V, Grecksch G. Repeated lysergic acid diethylamide in an animal model of depression: Normalisation of learning behaviour and hippocampal serotonin 5-HT2 signalling.J Psychopharmacol. 2014 28(6):545-52.

Zentralinstitut für Seelische Gesundheit (ZI) - https://www.zi-mannheim.de