Frölich L. Gemeinsamer Bundesausschuss : Patienten- und Versorgungsbezogener Nutzen der Amyloid-PET Bildgebung (ENABLE). 05/2024-12/2027.
Frölich L. EU - Europäische Union : Supple Graphene Bio-Platform for point-of-care early detection and monitoring of Alzheimer's Disease. 10/2023-09/2027.
Hector II Stiftung : FRAILBRAIN: Reversing maladaptive reorganization in frail brains: sensorimotor training, brain plasticity and the role of BDNF. 10/2016-09/2019.
Frölich L. BMBF - Bundesministerium für Bildung und Forschung 01ED1203J: BIOMARKAPD: Joint Programming Neurodegenerative Disease: Biomarkers for Alzheimer’s disease and Parkinson’s disease. 07/2012-06/2015.
Alzheimer’s and Parkinson’s diseases (AD and PD) are the two most common neurodegenerative
conditions. They cause major costs for the society and suffering and death for millions of patients
around the globe. In Europe, more than 8 million individuals have AD or PD. Current treatments are
symptomatic but do not stop the underlying disease process. Using biomarkers, we can detect
biochemical changes that show when neurons start to die. There are also biochemical tests for brain
changes that are specific to AD and PD. Studies suggest that such abnormalities start to appear 10-20
years before onset of symptoms. If we want to do something substantial about these diseases, we
need to diagnose them early, before too many neurons have been lost, and then treat them with drugs
that inhibit the destructive process. Such drugs are in development. However, in these disease stages
we cannot rely on clinical symptoms, as they may be very subtle, or even absent. Instead, research
tells us that we could use biomarkers for disease-specific pathologies. Established biomarkers exist
for early AD and promising candidates are underway for PD. However, a major problem today is the
lack of standardisation regarding exactly how to perform and use the biomarker tests. In
BIOMARKAPD we detail how we will standardise the biomarker measurements across Europe, how to
collect samples, how to perform the measurements and how to interpret the results. We will also
create a biobank with samples from well characterised AD and PD patients, including patients in very
early disease stages, as well as neurologically healthy controls. These samples will be used to
develop new and better assays and to test new and better biomarker candidates. Finally, we will
develop certified reference materials that can be used to harmonise assays that are used to measure
the different biomarkers. The deliverables of the proposal will have a major influence on clinical
research and drug development for neurodegenerative conditions in general and for AD and PD in
particular. They will impact these types of efforts globally and make Europe world-leading in this
arena.
Frölich L. BMBF - Bundesministerium für Bildung und Forschung 01KG0822: SIMaMCI-Study: Trial of Simvastatin in Amnestic Mild Cognitive Impairment (MCI) Patients (study site). 01/2009-12/2013.
Probands with MCI are at high risk to develop Alzheimer´s dementia (AD). Simvastatin may lower the production of Amyloid, a hallmark of AD in the brain. The primary hypothesis of the study is that Simvastatin significantly reduces the risk of conversion to Alzheimer's disease in individuals with MCI as compared to MCI receiving placebo.
Frölich L. EU - Europäische Union 211696: LipiDiDiet: THERAPEUTIC AND PREVENTIVE IMPACT OF NUTRITIONAL LIPIDS ON NEURONAL AND COGNITIVE PERFORMANCE IN AGING, ALZHEIMER’S DISEASE AND VASCULAR DEMENTIA. 08/2010-07/2013.
The European LipiDiDiet project addresses the Impact of Nutritional Lipids on Neuronal and Cognitive Performance in Aging, Alzheimer’s disease and Vascular Dementia. This is based on previous observations that lipids change the risk for dementia. Especially some omega-3 lipids appear to lower the Alzheimer risk. It is our major aim to complement the currently existing medical therapy of Alzheimer’s disease with nutrition, especially at the very first stages of Alzheimer’s disease. But we do not stop at Alzheimer’s, we also develop dietary products that maintain and support the normal cognitive function in healthy aging in general and help reduce cerebrovascular risks. In addition to dietary products we also develop diet and life-style based health care advice for the elderly.
The project is based on two elements; one is applied research documenting the value of nutritional support in persons at risk of getting Alzheimer’s disease. The other element is basic research generating more knowledge about the possible therapeutic and preventive effects of dietary lipids in model systems of Alzheimer’s disease and Vascular Dementia.