Broccoli L, Bernardi R, Giannone F, Hoppe A, Jüngling K, Borroto-Escuela DO, Rimondini-Giorgini R, Perez de la Mora M, von Bohlen und Halbach O, Fuxe K, Pape HC, Deussing JM, Spanagel R, Sommer WH, Hansson AC. Reducing stress and alcohol-related behaviors by targeting D1-CRHR1 receptor interactions in the amygdala. Front Pharmacol. 2025 16:1677510.
Ciccocioppo E, Massetti S, Meinhardt M, Fumagalli F, Romualdi P, Roberto M, Spanagel R, Ciccocioppo R, Domi E. (R)-Ketamine reduces alcohol intake and alcohol seeking induced by reconsolidation of alcohol-related memories in female Marchigian Sardinian alcohol-preferring rats. Psychopharmacology (Berl). 2025 Nov 15. [Epub ahead of print]
Ebrahimi C, Musial MPM, Doñamayor N, Prychynenko DS, Bode EL, Spanagel R, Heinz A, Deserno L, Smolka MN, Ebner-Priemer U, Kliegl R, Endrass T, Reichert M, Rapp M, Schlagenhauf F. Goal-directed behavior and hippocampal activity predict real-life impact of drinking intentions in alcohol use disorder. Transl Psychiatry. 2025 15(1):425.
Friske MM, Torrico EC, Haas MJW, Borruto AM, Giannone F, Hade AC, Yu Y, Gao L, Sutherland GT, Hitzemann R, Philips MA, Fei SS, Sommer WH, Mayfield RD, Spanagel R. A systematic review and meta-analysis on the transcriptomic signatures in alcohol use disorder. Mol Psychiatry. 2025 30(1):310-326. Epub 2024 Sep 6.
Habelt B, Talebi N, Afanasenkau D, Schwarz C, Knauer B, Meinhardt M, Spanagel R, Werner C, Minev IR, Beste C, Bernhardt N. Chronic alcohol-induced brain states limit propagation of direct cortical stimulation. Sci Rep. 2025 15(1):35407.
Heinz A, Gutwinski S, Friedel E, Bahr NS, Spanagel R, Chiara GD. Habitual Drug Intake Is Hard to Change: On the Discussion About Habits and Compulsions in Drug Addiction. Addict Biol. 2025 30(10):e70081.
Liu S, Haucke M, Groß R, Schneider K, Shin J, Arntz F, Bach P, Banaschewski T, Beste C, Deserno L, Ebner-Priemer U, Endrass T, Ganz M, Ghadami A, Giurgiu M, Heinz A, Kiefer F, Kliegl R, Lenz B, Marciniak MA, Meyer-Lindenberg A, Neubauer AB, Rapp M, Smolka MN, Strehle J, Spanagel R, Spitta G, Tost H, Walter H, Zech H, Reichert D, Reichert M. Real-time mechanism-based interventions for daily alcohol challenges: Protocol for ecological momentary assessment and intervention. Digit Health. 2025 11:20552076241311731.
Meinhardt M, Gerlach B, Spanagel R. Good Practice Guideline for Preclinical Alcohol Research: The STRINGENCY Framework. Curr Top Behav Neurosci. 2025 71:169-189. Epub 2023 Aug 9.
Meinhardt M, Skorodumov I, Jeanblanc J, Benvenuti F, Hilal FF, Domi E, André C, Bodeau S, Jeanblanc V, Domanegg K, Ciccocioppo R, Naassila M, Spanagel R. A new module in the drug development process: preclinical multi-center randomized controlled trial of R-ketamine on alcohol relapse. Neuropsychopharmacology. 2025 50(6):886-894. Epub 2025 Feb 28.
Müller CP, Lenz B, Kornhuber J, Ebner-Priemer UW, Schwarz E, Ersche KD, Kiefer F, Spanagel R. Phase-sensitive individualized pharmacotherapy for alcohol use disorder. Neuropharmacology. 2025 283:110745. Epub 2025 Oct 26.
Sommer WH, Spanagel R. Behavioral Neurobiology of Alcohol Addiction: A Decade of Great Challenges, New Hopes, and Hypes. Curr Top Behav Neurosci. 2025 71:3-16. Epub 2025 Jul 12.
Vetter S, Schnabel S, Reichl M, Sirignano L, Grinevich V, Koopmann A, Spanagel R, Kiefer F, Sommer WH, Bach P. Intranasal oxytocin blunts amygdala response to negative affective stimuli in males and females with alcohol use disorder: a randomized controlled cross-over trial. Psychopharmacology (Berl). 2025 242(9):1995-2007. Epub 2025 Mar 31.
Zillich E, Artioli A, Rossetti AC, Avetyan D, Belschner H, Frank J, Stein F, Schwarz JJ, Mechawar N, Turecki G, Nöthen MM, Hansson AC, Witt CC, Rietschel M, Koch P, Spanagel R, Zillich L, Witt SH. A multi-omics and cell type-specific characterization of the ventral striatum in human cocaine use disorder. Cell Rep. 2025 44(2):115332. Epub 2025 Feb 14.
Zillich L, Artioli A, Pohorala V, Zillich E, Stertz L, Belschner H, Jabali A, Frank J, Streit F, Avetyan D, Völker MP, Müller S, Hansson AC, Meyer TD, Rietschel M, Ladewig J, Spanagel R, Oliveira AMM, Walss-Bass C, Bernardi R, Koch P, Witt SH. Cell type-specific multi-omics analysis of cocaine use disorder in the human caudate nucleus. Nat Commun. 2025 16(1):3381.
Zillich L, D'Augello S, Avetyan D, Delgado GE, Gizer IR, Jung J, Katrinli S, Kleber ME, Merrill N, Moissl AP, Núñez-Ríos DL, Otto JM, Zillich E, Friedel E, Hancock DB, Johnson EO, Martínez-Magaña JJ, Nagamatsu ST, Sosnowski DW, White JD, Aberg KA, Copeland WE, Diazgranados N, Fani N, Gelernter J, Goldman D, Foo JC, Kranzler HR, Levey DF, März W, Penninx BWJH, Polimanti R, Powers A, Smith AK, Spanagel R, van den Oord EJ, Wilhelmsen KC, Witt SH, Domschke K, Schiele MA, Maher BS, Montalvo Ortiz JL, Clark SL, Lohoff FW. DNA Methylation Signatures of Alcohol Use Disorder - A large-scale Meta-Analysis in the Psychiatric Genomics Consortium. medRxiv. 2025