Abu-Rumeileh S, Scholle L, Mensch A, Großkopf H, Ratti A, Kölsch A, Stoltenburg-Didinger G, Conrad J, De Gobbi A, Barba L, Steinacker P, Klafki HW, Oeckl P, Halbgebauer S, Stapf C, Posa A, Kendzierski T, Silani V, Hausner L, Ticozzi N, Froelich L, Weishaupt JH, Verde F, Otto M. Phosphorylated tau 181 and 217 are elevated in serum and muscle of patients with amyotrophic lateral sclerosis. Nat Commun. 2025 16(1):2019.
Aye S, Johansson G, Hock C, Lannfelt L, Sims JR, Blennow K, Frederiksen KS, Graff C, Molinuevo JL, Scheltens P, Palmqvist S, Schöll M, Wimo A, Kivipelto M, Handels R, Frölich L, Zilka N, Tolar M, Johannsen P, Jönsson L, Winblad B. Point of view: Challenges in implementation of new immunotherapies for Alzheimer's disease. J Prev Alzheimers Dis. 2025 12(1):100022.
Benson GS, Bartels C, Stamatis F, Belz M, Esselmann H, Frölich L, Hausner L. The Use and Understanding of Mild Cognitive Impairment in Routine Specialist Care: A Survey Among German Memory Clinics. Geriatrics (Basel). 2025 10(1)
Bewernick B, Buschmann J, Heser K, Kleineidam L, Domschke K, Elsaesser M, Zehender N, Luppa M, Hellmich M, Peters O, Froelich L, Riedel-Heller S, Schramm E, Hautzinger M, Jessen F, Dafsari FS, Wagner M. The effect of cognition and age on the efficacy of psychotherapy in late-life depression. J Affect Disord. 2025 391:119881. Epub 2025 Jul 14.
Cesana BM, Poptsi E, Tsolaki M, Bergh S, Fabbo A, Frölich L, Jori MC, Defanti CA. A Confirmatory Factor Analysis of the Dementia Attitude Scale (DAS) in a European Case Series of Caregivers of People with Dementia Enrolled in the RECage Study. NeuroSci. 2025 6(2)
Cruchaga C, Timsina J, Jiang C, McCartney D, Tao F, Dalmasso MC, Najar J, Anastasi F, Ohlei O, Puerta R, Bradley J, Western D, Ali M, Wang C, Yang C, Wu Y, Liu M, Budde J, Williams J, Mahoney R, Castillo A, Hohman T, Dumitrescu L, Wang TC, Tesi N, Kern S, Waern M, Skoog I, van Harten A, van der Flier W, Sanchez-Juan P, Rodríguez-Rodríguez E, Kleineidam L, Peters O, Schneider A, Küçükali F, Bellenguez C, Grenier-Boley B, Heikkinen S, de Rojas I, Rujescu D, Scherbaum N, Hausner L, Düzel E, Grimmer T, Wiltfang J, Vandenberghe R, Engelborghs S, Heilmann-Heimbach S, Schmid M, Tegos T, Scarmeas N, Dols-Icardo O, Moreno F, Pérez-Tur J, Bullido MJ, Sánchez-Valle R, Alvarez V, García-González P, Mir P, Real L, Piñol-Ripoll G, García-Alberca JM, Seelaar H, Ramakers I, Papma J, Hulsman M, Laske C, Teipel S, Priller J, Perneczky R, Buerger K, Nöthen M, Lewczuk P, Kornhuber J, Maier W, Hampel H, Giegling I, Goldhardt O, Diehl-Schmid J, Andrade V, Heneka M, Froelich L, Vogelgsang J, Graff C, Thonberg H, Ullgren A, Papenberg G, Boland A, Deleuze JF, Wagner M, Jessen F, Holstege H, van Duijn C, Lebouvier T, Hanon O, Leinonen V, Soininen H, Herukka SK, Giedraitis V, Löwenmark M, Kilander L, Genius P, Rodríguez B, Luckett E, Navarro A, Cano A, Marquié M, Blennow K, Zetterberg H, Lleo A, Boada M, Laza AR, Lee V, Deerlin VV, Deming Y, Johnson S, Engelman C, Pastor P, Alvarez I, Peskind E, Heslegrave A, Saykin A, Nho K, Schindler S, Morris J, Holtzman D, McDade E, Renton A, Goate A, Ibanez L, Riemenschneider M, Albert M, Laws S, Porter T, O'Brien E, Shaw L, Tijms B, Ingelsson M, Visser PJ, Hiltunen M, Sleegers K, Ritchie C, Sims R, Lambert JC, Vilor-Tejedor N, Fernández M, Li Q, Nagle M, Marioni R, Ramirez A, Bertram L, van der Lee S. GWAS meta-analysis of CSF Alzheimer's disease biomarkers 18,948 individuals reveal novel loci and genes regulating lipid metabolism, brain volume and autophagy. Res Sq. 2025
Dodel R, Frölich L. Donanemab for Alzheimer's disease: from preclinical research to the clinical application. Expert Rev Neurother. 2025 25(10):1151-1163. Epub 2025 Aug 11.
Frederiksen KS, Boada M, Dubois B, Engelborghs S, Frisoni GB, Georges J, Hort J, Jönsson L, Kramberger MG, Ousset PJ, Scarmeas N, Schmidt R, Schott JM, Spiro L, Waldemar G, Winblad B, Jessen F, Frölich L. Navigating the introduction of anti-amyloid therapy in Europe: a position statement by individual members of the EADC. Alzheimers Res Ther. 2025 17(1):116.
Frisoni GB, Ribaldi F, Allali G, Bieth T, Brioschi Guevara A, Cappa S, Cipolotti L, Frederiksen KS, Georges J, Jessen F, Koch G, Masters H, Mendes AJ, Frölich L, Garibotto V, Grau-Rivera O, Pozzi FE, Religa D, Rostamzadeh A, Shallcross L, Shenkin SD, van der Flier WM, Vernooij MW, Visser LNC, Cummings JL, Scheltens P, Dubois B, Moro E, Bassetti CLA, Kivipelto M. Brain health services for the secondary prevention of cognitive impairment and dementia: Opportunities, challenges, and the business case for existing and future facilities. J Prev Alzheimers Dis. 2025 12(5):100098. Epub 2025 Mar 17.
Frölich L, von Arnim C, Bohlken J, Pantel J, Peters O, Förstl H. [Erratum to: Mild cognitive impairment in geriatric practice: patient orientation, diagnostics, treatment and ethics]. Z Gerontol Geriatr. 2025 58(4):341. Epub 2024 Sep 27.
Gebest M, Weiss C, Cho CG, Hausner L, Frölich L, Förster A, Santhanam N, Fontana J, Groden C, Wenz H, Maros ME. Longitudinal automated brain volumetry versus expert visual assessment of atrophy progression on MRI: an exploratory study. Sci Rep. 2025 15(1):14968.
Gerhards SK, Luppa M, Zülke AE, Pabst A, Claus M, Bewernick B, Elsaesser M, Zehender N, Wagner M, Peters O, Frölich L, Schramm E, Hautzinger M, Jessen F, Dafsari FS, Riedel-Heller SG. Educational attainment and cognitive behavioral therapy treatment outcome in late-life depression: A secondary analysis of a randomized controlled trial. J Affect Disord. 2025 380:576-583. Epub 2025 Apr 1.
Handels R, Hataiyusuk S, Wimo A, Sköldunger A, Bakker C, Bieber A, Ciccone A, Defanti CA, Fabbo A, Fascendini S, Frölich L, Gervès-Pinquié C, Gonçalves-Pereira M, Irving K, Koopmans R, Mecocci P, Merlo P, Michalowsky B, Peters O, Pijnenburg Y, Ribeiro Ó, Salbaek G, Schwarzkopf L, Verbeek H, de Vugt M, Woods B, Zanetti O, Winblad B, Jönsson L, Actifcare consortium, ICTUS/DSA group, PLASA/DSA group, RECAGE consortium, RightTimePlaceCare consortium . Informal care for people with dementia in Europe. J Prev Alzheimers Dis. 2025 12(1):100015.
Heser K, Dafsari FS, Kleineidam L, Kuss-Gondorf K, Luppa M, Peters O, Frölich L, Riedel-Heller S, Schramm E, Hautzinger M, Wagner M, Jessen F, Bewernick B. Depressive symptom factors and their differential association with psychotherapy outcomes in late-life depression: Results of the CBTlate study. J Affect Disord. 2025 390:119790. Epub 2025 Jun 30.
Jessen F, Arbizu J, Boada M, Balasa M, Bennys K, Boban M, Bürger K, Chincarini A, Cagnin A, De Deyn PP, Düzel E, Engelborghs S, Ewers M, Exalto LG, van der Flier WM, Fortea J, Frederiksen KS, Frisoni GB, Frölich L, Garza-Martínez AJ, Grimmer T, Hanseeuw B, Hort J, Ivanoiu A, Kehoe PG, Kennelly SP, Kern S, Klöppel S, Krajcovicova L, Kramberger MG, McGuinness B, Mecocci P, Oberstein TJ, Ousset PJ, Paquet C, Perneczky R, Piazza F, Plantone D, Rainero I, Sacco G, Salmon E, Santana I, Scarmeas N, Schneider A, Schott JM, Solje E, Stefanova E, Stögmann E, Strauss M, Sutovsky S, Waldemar G, Winblad B. Comment by European Alzheimer's Disease Consortium (EADC) investigators on the negative recommendation of the CHMP on the marketing authorization of donanemab for early Alzheimer' s disease. J Prev Alzheimers Dis. 2025 12:100259. Epub 2025 Jul 9.
Macfarlane S, Grimmer T, Teo K, O'Brien TJ, Woodward M, Grunfeld J, Mander A, Brodtmann A, Brew BJ, Morris P, Short C, Kurrle S, Lai R, Bharadwaj S, Drysdale P, Sturm J, Lewis SJG, Barton D, Kalafatis C, Sharif S, Perry R, Mannering N, MacSweeney JE, Pearson S, Evans C, Krishna V, Thompson A, Munisamy M, Bhatt N, Asher A, Connell S, Lynch J, Rutgers SM, Dautzenberg PL, Prins N, Oschmann P, Frölich L, Tacik P, Peters O, Wiltfang J, Henri-Bhargava A, Smith E, Pasternak S, Frank A, Chertkow H, Ingram J, Hsiung GR, Brittain R, Tartaglia C, Cohen S, Villa LM, Gordon E, Jubault T, Guizard N, Tucker A, Kaufmann WE, Jin K, Chezem WR, Missling CU, Sabbagh MN. Blarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial. J Prev Alzheimers Dis. 2025 12(1):100016.
Mendes A, Herrmann FR, Bergh S, Cesana BM, Handels R, Ciccone A, Cognat E, Fabbo A, Fascendini S, Frisoni GB, Frölich L, Jori MC, Mecocci P, Merlo P, Peters O, Tsolaki M, Defanti CA. Clinical Predictors of Mortality in People With Severe Behavioral and Psychological Symptoms of Dementia. J Am Med Dir Assoc. 2025 26(2):105374. Epub 2024 Nov 25.
Müller J, Elsaesser M, Berger R, Müller W, Hellmich M, Zehender N, Riedel-Heller S, Bewernick BH, Wagner M, Frölich L, Peters O, Domschke K, Jessen F, Hautzinger M, Dafsari FS, Schramm E. The Impact of Loneliness on Late-Life Depression and Anxiety During the COVID-19 Pandemic. Am J Geriatr Psychiatry. 2025 33(7):717-729. Epub 2025 Jan 21.
Perneczky R, Froelich L. Clinically meaningful benefit and real-world evidence in Alzheimer's disease research and care. Alzheimers Dement (N Y). 2025 11(2):e70090.
San Nicoló M, Mertzig S, Berghaus A, Peters O, Frölich L, Grimmer T, Wiltfang J, Oberstein T, Braun T, Babu M, Wunderlich H, Kaspar P, Baur G, Braun C, Bashiri M, Oehl H, Heydler T, Albert M. Novel, standardized sample collection from the brain-nose interface. Methods. 2025 234:233-241. Epub 2025 Jan 2.
Vollhardt A, Frölich L, Stockbauer AC, Danek A, Schmitz C, Wahl A. Towards a better diagnosis and treatment of dementia: Identifying common and distinct neuropathological mechanisms in Alzheimer's and vascular dementia. Neurobiol Dis. 2025 208:106845. Epub 2025 Feb 23.
Vromen EM, Lageman SB, Gobom J, van der Kant R, Dobricic V, Bertram L, Streffer J, Lovestone S, Vos SJ, Tainta M, Freund-Levi Y, Frölich L, Popp J, Peyratout G, Tsolaki M, Verhey F, Vandenberghe R, Schaeverbeke J, Blennow K, van der Lee SJ, Scheltens P, Pijnenburg YA, van der Flier WM, Teunissen CE, Zetterberg H, Visser PJ, Tijms B. Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease. Alzheimers Dement. 2025 21(10):e70738.
Wiels WA, Oomens JE, Engelborghs S, Baeken C, von Arnim CAF, Boada M, Didic M, Dubois B, Fladby T, van der Flier WM, Frisoni GB, Frölich L, Gill KD, Grimmer T, Hildebrandt H, Hort J, Itoh Y, Iwatsubo T, Klimkowicz-Mrowiec A, Lee DY, Lleo A, Martinez-Lage P, de Mendonça A, Meyer PT, Kapaki EN, Parchi P, Pardini M, Parnetti L, Popp J, Rami L, Reiman EM, Rinne JO, Rodrigue KM, Sanchez-Juan P, Santana I, Sarazin M, Scarmeas N, Skoog I, Snyder PJ, Sperling RA, Villeneuve S, Wallin A, Wiltfang J, Zetterberg H, Ossenkoppele R, Verhey FR, Vos SJ, Visser PJ, Jansen WJ, Amyloid Biomarker Study group , Alzheimer’s Disease Neuroimaging Initiative (ADNI), the A4 Study group, Dominantly Inherited Alzheimer Network (DIAN), European Prevention of Alzheimer’s Dementia (EPAD) consortium, Fundació ACE Healthy Brain Initiative (FACEHBI), Harvard Aging Brain Stud , Alcolea D, Altomare D, Baiardi S, Baldeiras I, Bateman RJ, Blennow K, Bottlaender M, den Braber A, van Buchem MA, Byun MS, Cerman J, Chen K, Chipi E, Day GS, Drzezga A, Eckerström M, Ekblad LL, Epelbaum S, Förster S, Fortea J, Freund-Levi Y, Frings L, Guedj E, Hausner L, Hellwig S, Huey ED, Jiménez-Bonilla JF, Johnson KA, Juaristi AI, Kandimalla R, Paraskevas G, Kern S, Kirsebom BS, Kornhuber J, Lagarde J, Landau SM, Legdeur N, Llibre Guerra JJ, Maserejian NN, Marquié M, Minatani S, Morbelli SD, Mroczko B, Ntanasi E, de Oliveira CR, Olivieri P, Orellana A, Perrin RJ, Peters O, Prabhakar S, Ramakers IH, Rodríguez-Rodríguez E, Ruiz A, Rüther E, Selnes P, Silva D, Soininen H, Spiru L, Takeda A, Teichmann M, Tijms BM, Teunissen CE, Thompson LI, Vogelgsangs J, Vöglein J, Waldemar G, Wallin AK, Yannakoulia M, Yi D, Zettergren A. Depressive Symptoms and Amyloid Pathology. JAMA Psychiatry. 2025 82(3):296-310. Epub 2025 Jan 22.