Tost H, Ebner-Priemer U. DFG - Deutsche Forschungsgemeinschaft : CRC TRR 265: Project A04: Intense characterization of triggers, modifying factors and mechanisms at course transition points in human addiction. 07/2019-06/2023.
The project will use ambulatory assessment and functional neuroimaging to identify triggers, modifying factors and intermediate neural mechanisms in alcohol use disorder (AUD) in course phases with a substantial increase or decrease in alcohol consumption, respectively. We will assess temporally highly resolved ambulatory assessment for six weeks to identify intraindividual differences in in the momentary effects of triggers and modifying factors on subjective craving, mood, impulsivity and alcohol consumption. We will further identify their neural correlates in brain circuits relevant for cognitive, affective and motivational processing and test the predictive value of the identified mechanisms for subsequent disease trajectories to critically inform novel prevention and intervention strategies.