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Andrea C. Rossetti

Postdoc

Department Translational Brain Research

RG Developmental Brain Pathologies

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Andrea is a postdoctoral fellow in the Ladewig lab. After his MSc in Biotechnology of the Drug, he obtained his PhD in Pharmacological Experimental and Clinical Sciences at the University of Milan, investigating the influence of neuroinflammation in the pathophysiology of psychiatric disorders.

He joined the lab to investigate the dynamics of brain development through human induced pluripotent stem cell models including cerebral forebrain organoids. The topics of his research involve the impact of neuroinflammation in the processes of cortical development and the modeling of Rett syndrome using cerebral forebrain organoid cultures. Andrea enjoys a lot to cook and share food with friends, drinking some good wine (or beer!) and exploring new musical experiences.

Publications in peer reviewed journals since 2006

TOP 5 publications:

  1. Jabali A, Hoffrichter A, Uzquiano A, Marsoner F, Wilkens R, Siekmann M, Bohl B, Rossetti AC, Horschitz S, Koch P, Francis F, Ladewig J. Human cerebral organoids reveal progenitor pathology in EML1-linked cortical malformation.EMBO Rep. 2022 23(5):e54027. Epub 2022 Mar 15.
  2. Zillich E, Artioli A, Rossetti AC, Avetyan D, Belschner H, Frank J, Stein F, Schwarz JJ, Mechawar N, Turecki G, Nöthen MM, Hansson AC, Witt CC, Rietschel M, Koch P, Spanagel R, Zillich L, Witt SH. A multi-omics and cell type-specific characterization of the ventral striatum in human cocaine use disorder.Cell Rep. 2025 44(2):115332. Epub 2025 Feb 14.
  3. Rossetti AC, Koch P, Ladewig J. Drug discovery in psychopharmacology: from 2D models to cerebral organoids
.Dialogues Clin Neurosci. 2019 21(2):203-224.
  4. Calabrese F, Rossetti AC, Racagni G, Gass P, Riva MA, Molteni R. Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity.Front Cell Neurosci. 2014 8:430.
  5. Rossetti AC, Paladini MS, Colombo M, Gruca P, Lason-Tyburkiewicz M, Tota-Glowczyk K, Papp M, Riva MA, Molteni R. Chronic Stress Exposure Reduces Parvalbumin Expression in the Rat Hippocampus through an Imbalance of Redox Mechanisms: Restorative Effect of the Antipsychotic Lurasidone.Int J Neuropsychopharmacol. 2018 21(9):883-893.

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