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Projekte: Neuroimaging des abhängigen Verhaltens

Ruprecht-Karls-Universität Heidelberg GRK 2350/1: Der Einfluss von Traumatisierung im Kindes- und Jugendalter auf psychosoziale und somatische Erkrankungen über die Lebensspanne, Projekt B5 "Stress sensitivity, emotion processing and cue-reactivity in substance-related disorders: the influence of ACE". 04/2019-09/2022.

TRR/1 TP C01: Losing and Regaining Control: TP Modifcation of the imbalance between goal-directed and habitual behavior. 07/2019-06/2022.

In this study, we aim to assess the imbalance between goal-directed and habitual behavior, its neural basis and how it can be differentially modified in treatment-seeking smokers, using two training interventions. The first intervention is cognitive remediation treatment (CRT), also known as cognitive enhancement therapy, focusing on improving inhibitory control and executive functions. The second intervention, a computer-based habit-modifying training focusing on implicit drug seeking ("implicit computer-based habit-modifying Training", ICHT) uses a conditioning approach through implicit priming and contextual modulation. We hypothesize that both interventions change the balance between goal-directed and habitual behavior but by different mechanisms. Whereas CRT should directly increase cognitive control, in contrast, ICHT should affect the early processing and the emotional valence of smoking and smoking cues.

Vollstädt-Klein S. DFG - Deutsche Forschungsgemeinschaft VO 2173/4-1: Investigating Neurobiological Mechanisms of Chess as an Add-On Treatment against Alcohol Use Disorder. 06/2019-05/2022.

The current project aims to investigate the potential mechanism of action of chess as a “cognitive remediation therapy” to reduce cognitive deficits in individuals with alcohol use disorder (AUD) seeking treatment using neurobiological and neuropsychological approaches. Furthermore, we will assess whether this chess intervention has a generalized positive effect on short-term abstinence. Interestingly, the functional domains and associated underlying neuronal networks observed to be affected in individuals with AUD overlap significantly with those that could be strengthened by chessbased cognitive training or formal chess. Specifically, strengthening of cortical control regions (dorsolateral prefrontal cortex, DLPFC) and brain areas relevant for decision-making (orbitofrontal cortex, OFC) could prevent future relapse. Therefore, chess as an add-on therapy to complement other standard treatments of AUD could lead to improved therapeutic outcomes.

Zentralinstitut für Seelische Gesundheit (ZI) -