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Dr. Quirin Krabichler

Postdoc

Abteilung Neuropeptidforschung in der Psychiatrie

Tel.: 0621 1703-2997

E-Mail

Laborgebäude, Raum 3.23

About me

I am interested in understanding how the brain regulates behaviours and physiological states via neuropeptidergic signaling. My main focus in this respect is currently the role of central arginine vasopressin (AVP) circuits in pain, fear and stress. In addition, I am very interested in the neural plasticity induced by lactation during motherhood, an extreme physiological challenge leading to a complex cellular and circuit-level reorganization in the brain. To study these phenomena, I am applying novel transgenic rat models, viral vectors, chemogenetics, optogenetics, advanced light microscopy, and quantitative 3D image analysis techniques. In addition, I am collaborating on various other projects related with oxytocinergic and vasopressinergic brain circuits.

Quirin holds a PhD in comparative neuroscience (summa cum laude) and an M.Sc. and a B.Sc. in Biology. He is a senior staff scientist in our team, and he is head of the Core Unit Microscopy at the Core Facility Preclinical Research.
 

Expertise

Opto-/ChemogeneticsStereotactic injections
Behavioral analysisFiber Photometry
Publikationen in peer-reviewed Zeitschriften seit 2006

TOP 5 Publikationen:

  1. Iwasaki M, Lefevre A, Althammer F, Clauss Creusot E, Łąpieś O, Petitjean H, Hilfiger L, Kerspern D, Melchior M, Küppers S, Krabichler Q, Patwell R, Kania A, Gruber T, Kirchner MK, Wimmer M, Fröhlich H, Dötsch L, Schimmer J, Herpertz SC, Ditzen B, Schaaf CP, Schönig K, Bartsch D, Gugula A, Trenk A, Blasiak A, Stern JE, Darbon P, Grinevich V, Charlet A. An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats.Nat Commun. 2023 14(1):1066.
  2. Barton S, Zovko A, Müller C, Krabichler Q, Schulze J, Wagner S, Grinevich V, Shamay-Tsoory S, Hurlemann R. A translational neuroscience perspective on loneliness: Narrative review focusing on social interaction, illness and oxytocin.Neurosci Biobehav Rev. 2024 163:105734. Epub 2024 May 23.
  3. Gruber T, Lechner F, Murat C, Contreras RE, Sanchez-Quant E, Miok V, Makris K, Le Thuc O, González-García I, García-Clave E, Althammer F, Krabichler Q, DeCamp LM, Jones RG, Lutter D, Williams RH, Pfluger PT, Müller TD, Woods SC, Pospisilik JA, Martinez-Jimenez CP, Tschöp MH, Grinevich V, García-Cáceres C. High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling.Cell Rep. 2023 42(10):113305. Epub 2023 Oct 20.
  4. Francesconi W, Olivera-Pasilio V, Berton F, Olson SL, Chudoba R, Monroy LM, Krabichler Q, Grinevich V, Dabrowska J. Vasopressin and oxytocin excite BNST neurons via oxytocin receptors, which reduce anxious arousal.Cell Rep. 2025 44(6):115768. Epub 2025 Jun 3.
  5. Zhang L, Zetter MA, Hernandez VS, Hernández-Pérez OR, Jáuregui-Huerta F, Krabichler Q, Grinevich V. Morphological Signatures of Neurogenesis and Neuronal Migration in Hypothalamic Vasopressinergic Magnocellular Nuclei of the Adult Rat.Int J Mol Sci. 2024 25(13).

Zentralinstitut für Seelische Gesundheit (ZI) - https://www.zi-mannheim.de