Start Forschung Abteilungen / AGs / Institute Neuropeptidforschung in der Psychiatrie Live, Love, Oxytocin! Viral Vectors

Viral Vectors

By removing the ability to replicate, Adeno associated viruses can be used as a safe tool to deliver small sequences of genetic information into neurons and other brain cells. The targeting of those neurons is highly specific and allows us to express the genes only in cells of interest. Those could be Oxytocin producing neurons or Oxytocin receptor expressing neurons in distinct regions of the brain.

We specialised in the developement and production of a variety of AAVs which not only allow specific cell targeting but also endogenous stimulation or inhibition. A full list of our currently available viruses can be found below:

NR. Construct Map Datum
A 48 OTp_iCreW Map 08.11.17
A 51 A51     pAAV-6P-Vsp-Venus Map 12.04.17
A 66 AAV-CbA-cre-Ires-GFP (96a) Map 21.10.15
A 68 AAV-CBAcre Map 16.04.20
A 69 Syn p_tdTomato Map 03.02.15
A 71 CBAp_TVA_IRES_tdTomato Map 15.11.17
A 75 VPp(1.9)_tdTomato   04.11.15
A 77 AAV-Oxy dttom(AAV-OTp-tdTomato) Map 02.07.14
A 82 VPp(1.9)_iDTR_IRES_EGFP   30.07.14
A 83 VPp(1.9)_TVA_IRES_tdTomato   15.02.10
A 85 AAV_OTp_Venus (OT-V) Map 11.10.17
A 89 AAV_OTp_ChR2-mcherry Map 21.06.17
6.12.18
A 90 VPp(1.9)_ChR2-mCherry (-WPRE) Map 24.05.17
A 92 AAV_EF1a p-DIO_hCHR2(H13R)-EYFP Map 19.10.13
A 96 AAVCAG-Flex-ChR2mcherry RW JFRC,Sternson   5.03.14
A101 VPp(1.9)_iCre_IRES_EGFP Map 08.11.17
19.08.20
A103 AAV_VPp_Venus Map 13.11.13
28.09.16
A107 VPp(1.9)_RG Map 15.02.10
A109 AAVEF1a p_DIO_TTLC-ko Map 05.07.17
A110 AAV_VPp_TTLC_ko(+Wpre Map 03.09.13
A111 AAV_OTp_TTLC-ko(-Wpre Map 02.08.13
A112 AAV_CamKIIa p_Arch3.0-EYfP Map 25.04.13
A113 AAV_CamKIIa p-hCHR2(134a)-mcherry Map 25.04.13
A121 EF1a p_ DIO_ Synatophysin-GFP Map  
A125 AAV_OTp_HaloR Map  
A126 AAV_EF1a p_miRNAoxyR1 Map 06.06.13
A127 AAV_EF1a p_miRNAoxyR2 Map 29.05.13
A128 AAV_EF1a p_miRNAoxyR3 Map 06.06.13
A129 AAV_EF1a p_miRNAoxyR4 Map 27.06.13
A130-133 pAAV_EF1a_miRNAVasR20-23 Mix(Judith8) Map 05.03.14
A137 pAAV_EF1a-DIO_ mcherry WPREpA Map 24.03.17
14.04.20
A139 EF1a-DIO p_GFP  Map 23.07.13
A140 AAV_CMVp_Tre_CHR2-YFP   03.07.13
A141 AAV_CMVp_hm4D-mcherry   02.08.13
A142 AAV_OTp_htArch3.0-EYFP Map 08.08.13
A143 AAV_EF1a p_DIO_EYFP_WPR Map 10.10.18
20.02.19
A144 EF1a p _DIO_EYFP_WPRE_ires_CR Map 11.07.13
A147 AAV_tetbi p_YC3.6_icre   18.10.17
A148 AAV_tet07 p_fos_rtTA Map 09.07.14
06.03.19
A151 AAV_OTp_DIO_TTLC-ko Map 13.08.13
A152 AAVOxypAGFP Map 19.03.14
A153 AAV_Otp_Oxygene7.5_Wpre Map 12.02.14
A154 AAV_VPp_CREB3L1 Map 13.11.13
A157 AAV_Otp_Oxygene8.5_WPRE Map 12.02.14
A158 AAV_OTp_DIO_GFP Map 14.05.14
A160 AAV-Syn p_DIO_H2B-RFP   28.01.14
A161 AAV CamKII-DIO EYFP   22.02.17
A162 AAV_EF1a p-DIO_HaloR   19.12.13
A163 cfos p cre ERT2 Map 12.02.14
A164 AAVEFdoublefloxed HR-EYFP Map 26.03.14
A165 AAVOTp_CREB3L1 Map 08.11.17
A168 AAV_Opto_oxy-4 Map 29.07.11
A171 pAAV_EF1a_DIO_hChR2(H134R)-mCherry-WPRE- Map 12.03.14
6.03.19
14.04.20
A172 AAV_syn_DIO_hM3DGqmcherry Map 16.04.15
A175 pAAV-OxyP_hNPY-mcherry-WRE (Judith19) Map 12.03.14
A176-179 AAVEF miRNA VasR mix Map 19.03.14
A180 AAV_OTp_hM3D(Gp)-mcherry Map 11.07.18
06.03.19
30.01.19
A181 AAV_OTp_hM4D(Gi)-mcherry Map 22.08.18
A182 AAV-OTp_NPY-phluorino(mit WRE) Map 30.04.14
A183 AAV-OTp_NPY-phluorino(ohne WRE)  Map 30.04.14
A184 AAV_SYNstop hM3D(Gi)-mCherry  Map 07.05.14
A185 AAV_SYNstop hM3D(Gq)-mCherry Map 07.05.14
A187 AAVOTp-oxygeneElephant7.5 Map 06.08.14
A188 AAVOTp_DIO CHR2(H134)_mcherry Map 20.08.14
A190 VPpromoter-pKillerred-mem(Evrogen Map 13.08.14
A191 AAVOTp_GCamP6f3 Map 10.09.14
A192 AAV_OTp_GCamP6s Map 23.08.17
01.08.18
A193 AAV-VasP-taCasp3-TEVp Map 08.10.14
A194 AAV_VasP_HR-EYFP wo WER Map 21.01.15
A195 AAVOTp-DIO_ChR2-EYFP Map 22.10.14
A196 AAVOTp-Dio_HR-EYFP Map 22.10.14
A197 AAVOTp-ChR2-EYFP   05.11.14
A200 AAV-EF1a-GFP Map 09.02.15
A201 AAV-Ef1a-mcherry Map 09.02.15
A203 AAV-OTp-C1V1(t/t)-TS-mcherry Map 01.04.15
A204 AAV-EF1a -C1V1(t/t)-TS-mcherry Map 01.04.15
A205 Aav-Gfa-C1V1-TS mcherry( Mit AAV 1/2) Map 29.06.16
10.10.16
A206 AAVCaMKII-hM3D(Gq)-mCherry   01.07.15
A207 pAAVCAMKII_hM4D(Gi)mcherry Map 01.07.15
A208 AAVOTp_DIO_mcherry -wre5 Map 22.07.15
A211 AAV_Otp_mcherry Map 29.06.16
A212 AAV_Otp_DIO_gCam6s Map 07.10.15
A213 AAV_synP_Campari Map 28.10.15
A214 AAV_Otp_Campari Map 25.11.15
A215 AAV_EF1a_DIO_NPY-mcherry Map 25.11.15
A216 pAAVEF1a_DIO_NPY-phluorino Map 02.12.15
A218 pAAVEF-DIO-Campari Map 09.12.15
A220 pAAVVa(1.9)HUsHshRNA 1 Map 16.12.15
A221 pAAVVa(1.9)HUsHshRNA 2 Map 16.12.15
A222 pAAVVa(1.9)HUsHshRNA3 Map 03.02.16
A223 pAAVVa(1.9)HUsHshRNA4 Map 03.02.16
A224 pAAVVa(1.9)HUsHshRNA 5 Kontrolle Map 10.02.16
A225 AAV_EF1a_OTR-ires_GFP Map 17.02.16
A226 AAVVasHspa5 Map 10.02.16
A227 AAV_EF1a_DIO_OTr_ires_GFP.(64 Map 13.04.16
A228 AAV-OTp-HA_Kordes_ires_mCitrine   Map 17.02.16
A229 AAV_OTp-DIO-HA_Kordes_ires_mCitrine Map 06.04.16
A230 AAVEF1a-DIO-SynaptophysinEGFP (Deussing) Map 11.05.16
24.10.18
A231 AAVOTp_DIO_RG (67-2   06.04.16
A234 AAVOTp_DIO_mRFPiresT800   27.04.16
A236 AAV-C-fos rtTA  Map 01.06.16
A238 AAVgfaA-GCamP6s3 Map 27.07.16
A239 pAAVEF1a GCamP6s3 WPr epA Map 10.08.16
A244 AVOTp_RG (76) Map 26.10.16
A246 A246 AAVGFAP-hM4D6i-mcherry (77) Map 30.11.16
A247 AAV_GFAP-DIO GCaMP6 Map 30.11.16
A248 AAVEF1a_DIO_C1V1-mcherry Map 07.12.16
A249 pGFAP-DIO_C1V1mcherry Map 07.12.16
A251 AAV EF1a-DIO_hM3D(Gq)-mcherry Map 21.01.17
24.09.18
A252 AAV EF1a-DIO_hM4D(Gi)-mcherry (84) Map 21.01.17
24.10.18
09.04.20 
A253 AAVTHprom_GFP(82 Map 24.05.17
A254 AAVTHprom ChR2-mcherry Map 24.05.17
A255 AAVOTp-DIO-mcherry(-WRE)(87) Map 24.05.17
A256 AAV-Otp-ROBO2 Map 24.05.17
A257 VasP -hM3D(Gp) (89) Map 26.07.17
A258 AAV-VasP-hM4D(Gi) Map 16.08.17
A259 pAAV-EF1a-DIO HA-UPRT_ires-EYFP (91) Map 30.08.17
A260 AAVEF1a-C1V1mcherry Map 30.01.18
A261 AAVOTp-DIO-hM4D(Gi)-mcherry Map 14.12.17
A262 AAV.CamKII-HeleroEYFp(94) Map 14.12.17
A263 AAVOTp-DIO-hM3D(Gq)mcherry(95) Map 24.01.18
A264 AAVVasP-GcamP6s3 Map 07.03.18
A265 AAVOTpsynGFP Map 26.10.16
A266 pAAV-Ef1a-DIO-oG-WPRE-hGH Map 20.06.18
A267 AAV-OTp-ihres-icre Map 20.06.18
A268 AAVOTpT800-ires-tom(98) Map 11.07.18
A269 AAV-CAG-DIO-TCB. Map 08.08.18
A270 AAVGfa-GFP-ihres-icre Map 24.09.18
A271 AAV-Ef1a-DIO-GCamP6s3 Map 10.10.18
A272 AAVOTp-oxytocin-ihres-V Map 12.02.19
16.04.20
A273 AAV-OTp-oG   20.02.19
06.03.19
A274 AAV_EF1a-DIO-H2B-GFP-2A-oG-WPRE-hGH Map 09.07.2020
A275 AAV_OTp_oG_mcherry Map 03.06.2020
A276 AAV_GFAP_OptoGq_EYFP   15.04.2020
A277 AAV_GFAP_OptoGq_mcherry   09.07.2020
A278 OTp_ChrimsonR_mScarlet   19.08.2020
A279 Syn_jRCaMP1a   22.07.2020
A280 OTp-jRCaMP1a   22.07.2020
A281 GFAP_jRCaMP1a   03.06.2020
A282 Ef1a_DIO_taCasp3_TEV    
       
       
       
       

 



Zentralinstitut für Seelische Gesundheit (ZI) - https://www.zi-mannheim.de