integration will be performed and a priority candidate gene list for the entire SPP1226 will be generated. From this priority gene list for nicotine addiction we will functionally validate the top hits in [...] the nucleus accumbens shell). The advent of AAV vectors carrying cDNA for, or short hairpin RNA against, specific genes allows now for the first time the rapid bidirectional manipulation of gene function [...] Effekte im Zentralen Nervensystem (ZNS). 09/2009-09/2012. Abstract Background: Consistent evidence for the heritability of smoking behaviours has led to genetic studies designed to elucidate the specific
development of an IT infrastructure for geographically distributed application for machine learning, and the encoding of mechanistic knowledge in the form of knowledge graphs for downstream application of artificial [...] As core data acquisition site for the Longitudinal European Autism Project (LEAP), CIMH will reassess the local participants for the LEAP wave 3. CIMH will be responsible for the core analysis of the LEAP [...] emergency situations, and no financing for language services is available for many hospitals, this presents a critical obstacle in providing mental health care for refugees. This consortium will leverage
development of an IT infrastructure for geographically distributed application for machine learning, and the encoding of mechanistic knowledge in the form of knowledge graphs for downstream application of artificial [...] profiles for illness course, treatment response and occurrence of comorbidity during early illness phases. With this, COMMITMENT will provide the basis for biologically-informed clinical tools for improved [...] deficits relevant for a given patient. Among these, psychomotor abnormalities represent a core clinical feature with transdiagnostic importance in SZ and MDD, but their relevance for individualizing t
c pharmaco-treatment strategy for schizophrenia . Mol Psychiatry . 2025 30(7):2891-2906. Epub 2025 Jan 17. Lenz B , Derntl B. Sex-sensitive and gender-sensitive care for patients with mental disorders [...] Group) . Reductions in World Health Organization Risk Drinking Levels as a Primary Efficacy End Point for Alcohol Clinical Trials: A Review . JAMA Psychiatry . 2025 Sep 17. [Epub ahead of print]
groundwork for future multi-site randomized controlled trials to investigate effectivity of the approach. It is the first time that neurofeedback is used to boost psychotherapy outcomes for patients with [...] Deutscher Akademischer Austauschdienst : Methods for real-time BOLD signal extraction. 01/2019-12/2020. Abstract To identify optimal signal processing parameters for successful brain self-regulation training [...] real-time fMRI neurofeedback study . 10/2024-06/2028. AE Foundation: BrainBoost A Neurofeedback Booster for Emotion Regulation Therapy. 07/2020-12/2022. Abstract In the planned set of studies, we will use n
Prof. Dr. Christian Beckmann , Donders Institute for Brain, Cognition and Behaviour: statistical neuroimaging Prof. Dr. Andre Marquand , Donders Institute for Brain, Cognition and Behaviour, statistical n [...] Medical Faculty, Philipps-University Marburg, Marburg, Germany): ADHD research Stefan Bender (Section for Clinical Neurophysiology and Multimodal Neuroimaging, Child and Adolescent Psychiatric Department, [...] of Psychology, University of Potsdam, Germany): Parent-child interaction Friedhelm Pfeiffer (Centre for European Economic Research, Mannheim, Germany): Non-cognitive skills Martina Pitzer (Department of
development of an IT infrastructure for geographically distributed application for machine learning, and the encoding of mechanistic knowledge in the form of knowledge graphs for downstream application of artificial [...] products for the treatment of alcohol addiction provided by the European Medicines Agency (EMA), will adhere to the standards proposed for confirmatory biomedical research (Dirnagl, 2016) for nonclinical [...] emergency situations, and no financing for language services is available for many hospitals, this presents a critical obstacle in providing mental health care for refugees. This consortium will leverage
rtner Centre for Society and Mental Health, King's College London Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Center for Epidemiology [...] and Public Health, Institute of Psychiatry, Psychology & Neuroscience, King’s College London Center for Contextual Psychiatry, KU Leuven Heidelberg Institute of Global Health University, Medical Faculty [...] Aktuelle Studien der Abteilung Public Mental Health Kompetenznetz Public Health COVID-19 ESRC Centre for Society & Mental Health Wietse Tol: Towards structurally informed and integrated approaches to global
Recording Strategy for Europe) is to advance the transformation of mental health care in Europe into true person-centered care, focused on the needs of each individual seeking help for mental health problems [...] Europe representing different contexts for implementation evaluation. At the same time, IMMERSE will identify and overcome key barriers and strengthen facilitators for implementation, transfer and scale-up [...] Science Alliance Heidelberg Mannheim : The advancement of interpretable machine learning/AI techniques for the reconstruction of dynamical systems and the forecasting of empirical time observation series.
provides a physiologically relevant platform for modeling neuropsychiatric disorders and testing therapeutics. The findings will establish a robust foundation for future funding applications, refine organoid [...] PBMCs and iPSC-derived neurons for the validation of schizophrenia biomarkers . 09/2021-08/2024. Abstract An objectively measured and evaluated biomarker used as an indicator for a pathogenic process or ph [...] corresponding patients are at hand and serve for sequencing blood transcriptomes and the establishment of multi-modal disease signatures in SP1 and SP2. For biomarker validation, those iPSC specimens will
