neural networks that trigger aggressive behavior. In terms of treatment, only limited efficacy has been reported, possibly attributable to the presence of distinct (e.g. arousal- specific) subgroups within [...] functioning contributes to the emergence of aggressive behavior. Moreover, specific arousal patterns have been shown to distinguish CD patients with and without CU traits, which paves the way for an individualized

established the routine generation of iPSC lines from mouse and humans (almost 20 m/hiPSC lines have been generated), (iii) analyzed opioid and dopamine system adaptations at both transcriptional and protein

chronic alcohol exposure. However, a detailed assignment of those changes to specific cell types has not been performed due to technical limitations and lack of appropriate tissue. In this planned consortium

evaluate particularly positive information referenced to themselves as less positive and this has been related to an internal, negative and global attributional style. They feel less included during positive [...] state. During reconsolidation memory can be disrupted, modified or even enhanced. It has recently been demonstrated that oral administration of the β-adrenergic receptor antagonist propranolol during memory

specific for the extensive comorbidity of pain and depression have not been characterized, plasticity in these circuits has not been examined, and the causal status of any neural systems abnormality is unclear [...] longitudinal and multi-modal imaging information at hand has not yet been exploited. After psychiatric neuroimaging research has long been focusing on dedicated regions in the brain (local analysis), the emerging [...] 07 - Neural circuits involved in Phantom Limb Pain . 07/2019-06/2023. Abstract Although there has been much progress in the understanding of phantom limb pain (PLP), we still do not know which factors

both predict rewards and suppress interactions of mPFC and NAc. We will focus on the NAc that has been proposed to serve as a central gateway where converging inputs help to optimize reward outcome. Yet

specific for the extensive comorbidity of pain and depression have not been characterized, plasticity in these circuits has not been examined, and the causal status of any neural systems abnormality is unclear [...] longitudinal and multi-modal imaging information at hand has not yet been exploited. After psychiatric neuroimaging research has long been focusing on dedicated regions in the brain (local analysis), the emerging [...] y stressful. However, scientific evaluation of this assumption is scarce.Specifically, it has not been studied whether models of depression or schizophrenia, to name two most common and severe psychiatric

and depression (S&D) every year, there have been few truly innovative new chemical entities (NCEs) which have made it to the clinic. While there has been a tremendous explosion of new knowledge: dozens [...] pathways identified, numerous imaging findings differentiating patients from controls, yet, it has been hard to take these findings from the bench to the clinic. We think there are three major bottlenecks

chronic alcohol intake leads to neuroinflammation that in turn triggers addictive behaviour. It has been shown that intranasal delivery of mesenchymal stem cell-derived exosomes reduces relapse behaviour

prevalence in Germany, 260 million € annual cost, Schlander, Trott and Schwarz, 2010). It has even been argued that the disorganization of time and the inability to accurately perceive its passage lies