innovative interventions for prevention and early intervention of mental ill-health in youth, that have been developed and tested in co-creation with youth: 1) walk-in youth mental health support centres, o
to improve treatment research (1). Besides the domains represented in the MATRICS battery, it has been shown that metacognitive capacities are impaired in schizophrenia, leading to a reduced ability to [...] e of delusions (8-10). Specific therapeutic interventions to improve metacognitive functions have been developed and tested in several controlled trials (11). In the present application, we mainly focus
peripheral effects of OT for maternal behavior (such as milk ejection and uterus contractions) have been studied exceedingly, the functions of OT particularly in higher order brain areas are less well e
and depression (S&D) every year, there have been few truly innovative new chemical entities (NCEs) which have made it to the clinic. While there has been a tremendous explosion of new knowledge: dozens [...] for patients with therapy-refractory depression [5-9]. Abnormal function of the lateral habenula has been directly linked with major depression [10; 11]. We now aim to express genetically engineered receptors [...] future alternative to deep brain stimulation (DBS). Resting state functional connectivity fMRI has been extensively established at our high field animal scanner [20]. After setting up resting state fMRI
basis that emphasizes one behaviour over another. Recently, in healthy young participants, sleep has been shown to interact with these reward signals that strengthen rewarded information more strongly than
temporal trajectories and related pathomechanisms across individuals and symptom clusters. PMDD has often been treated as a homogeneous condition across individuals and stable over cycles in both clinical and [...] negative emotions in patients with NSSI. However, proximal antecedents and consequences of NSSI have not been studied comprehensively in the daily life of BPD patients so far. Consequently, we aim to investigate
and depression (S&D) every year, there have been few truly innovative new chemical entities (NCEs) which have made it to the clinic. While there has been a tremendous explosion of new knowledge: dozens [...] for patients with therapy-refractory depression [5-9]. Abnormal function of the lateral habenula has been directly linked with major depression [10; 11]. We now aim to express genetically engineered receptors [...] future alternative to deep brain stimulation (DBS). Resting state functional connectivity fMRI has been extensively established at our high field animal scanner [20]. After setting up resting state fMRI
this may vary with sex, pain dynamics and the context in everyday life. While chronic stress has been shown to induce sensitization to pain (allodynia), initial studies in rats suggest that OT inhibits [...] mechanisms in relation to social influences on pain processing in chronic pain disorders have not been investigated yet. Grinevich V. Georgia State University : Inverse neurovascular coupling in the h [...] memory representations, in this project we focused on the ventral hippocampus (vHippo), which has been recently reported as a controlling social memory hub. Intriguingly, the experimental inhibition of
and to validate the neurochemical prediction from SP8 via in vivo microdialysis. Major progress has been made in in vivo tetrode recordings and we have examined the effect of acute alcohol treatment in the
disorder, it might give rise to subtle motor abnormalities. In this context, subtle motor deficits have been suggested to be an external marker of underlying neuronal dysfunction that is linked with an elevated [...] several important and innovative hypotheses while focusing on three study samples. So far, there has been no previous research combining this diverse set of novel neuroimaging methods with advanced data analysis
