Amide Hydrolase in Comorbid Borderline Personality Disorder and Major Depressive Disorder: Imaging with [C]CURB PET . Neuropharmacology . 2025 273:110436. Epub 2025 Mar 28. Dwyer JB, Schmahl C , Makinodan [...] Sommer S, Wruck J, Jelaska A, Adeniji A, Goodman M. Efficacy and Safety of BI 1358894 in Patients With Borderline Personality Disorder: Results of a Phase 2 Randomized, Placebo-Controlled, Parallel Group
namely a preclinical multicenter placebo controlled trial in rats with a step-wise translation into a naturalistic pilot trial with ambulatory assessment in alcoholic patients. As a comparator, we will [...] time-intensive discussions with regulatory bodies, dose determination and finally cost-intensive phase II clinical testing for psilocybin in alcoholics, we propose for the first time with respect to mental disorders [...] led, Parallel-Group Study to Assess the Efficacy, Safety, and Tolerability of BIIB080 in Subjects with Mild Cognitive Impairment Due to Alzheimer’s Disease or Mild Alzheimer’s Disease Dementia. 05/2024-12/2027
Amide Hydrolase in Comorbid Borderline Personality Disorder and Major Depressive Disorder: Imaging with [C]CURB PET . Neuropharmacology . 2025 273:110436. Epub 2025 Mar 28. Dwyer JB, Schmahl C , Makinodan [...] Sommer S, Wruck J, Jelaska A, Adeniji A, Goodman M. Efficacy and Safety of BI 1358894 in Patients With Borderline Personality Disorder: Results of a Phase 2 Randomized, Placebo-Controlled, Parallel Group
context conditioning and that larger amygdala volume is associated with better cue conditioning, whereas cue conditioning is reduced with larger hippocampal volume. We also found that polymorphisms related [...] been associated with high risk for schizophrenia and memory disturbance, was found to predict hippocampal activation during context conditioning. In addition, traumatized persons with and without PTSD [...] stress analgesia in the patients with PTSD and this was linked to enhanced activation in the rostral anterior cingulate. We also observed better second order conditioning with trauma cues as unconditioned
in Psychiatry. My research investigates the neural mechanisms underlying positive affective states, with a particular focus on playful behaviors in rodents. By combining in vivo electrophysiology, behavioral [...] works as the group leader of the research group for neurobiology of positive emotions and was awarded with the Young Investigator Award of the Japan Neuroscience Society (JNS). Expertise Ultrasonic vocalizations
The Association Between Newer Generation Antidepressants and Insomnia in Children and Adolescents With Major Depressive Disorder . J Am Acad Child Adolesc Psychiatry . 2025 64(10):1148-1164. Epub 2025 [...] administration reduces alcohol craving and cue-induced nucleus accumbens activation in individuals with alcohol use disorder: the double-blind randomized controlled ICONIC trial . Mol Psychiatry . 2025
The Association Between Newer Generation Antidepressants and Insomnia in Children and Adolescents With Major Depressive Disorder . J Am Acad Child Adolesc Psychiatry . 2025 64(10):1148-1164. Epub 2025 [...] administration reduces alcohol craving and cue-induced nucleus accumbens activation in individuals with alcohol use disorder: the double-blind randomized controlled ICONIC trial . Mol Psychiatry . 2025
The Association Between Newer Generation Antidepressants and Insomnia in Children and Adolescents With Major Depressive Disorder . J Am Acad Child Adolesc Psychiatry . 2025 64(10):1148-1164. Epub 2025 [...] administration reduces alcohol craving and cue-induced nucleus accumbens activation in individuals with alcohol use disorder: the double-blind randomized controlled ICONIC trial . Mol Psychiatry . 2025
The Association Between Newer Generation Antidepressants and Insomnia in Children and Adolescents With Major Depressive Disorder . J Am Acad Child Adolesc Psychiatry . 2025 64(10):1148-1164. Epub 2025 [...] administration reduces alcohol craving and cue-induced nucleus accumbens activation in individuals with alcohol use disorder: the double-blind randomized controlled ICONIC trial . Mol Psychiatry . 2025
learning on cultural differences in social cognition with a cross-sectional approach by comparing participants from China and Germany who live abroad with those who never lived abroad. EU - Europäische Union [...] in animals, and which can be transferred to humans. With our highly interdisciplinary EU consortium (PIs from seven European countries and Israel with outstanding expertise) it is expected that after having [...] specific neurobiological mechanisms associated with therapy response as well as particular neurobiological signatures before treatment that are associated with treatment response. Results should further allow
