human brain development and found that lysosomes are asymmetrically inherited by the two daughter cells. Lysosomes are a specialized subset of vesicles and are commonly considered the cellular ‘garbage disposal’ [...] receptors are regulated by a variety of mechanisms including the internalization from the surface into subcellular vesicles of the dividing cell. Via these, so called endosomes, the receptors are concentrated [...] and his team followed how Notch receptors are processed in the cells. Using live cell imaging they found that soluble ligands specific for Notch receptors are internalized upon binding and that this r

site. “With the Competence Center, we are creating a place where knowledge is pooled, concrete perspectives for action are developed, and the various stakeholders are called upon to take action.” “Today [...] particular are closely linked to issues of mental health. With the competence center, we want to use scientific evidence to show how digital experiences can be successful so that young people are strengthened [...] strengthened in their personality development, potential stressors are cushioned at an early stage, and prevention approaches are specifically promoted.” Broad dialogue initiated Mareike Lotte Wulf, Parliamentary

Publications are considered “highly cited” if, among other things, they are among the “top 1 percent” of the most cited publications in a particular scientific field. 6,602 researchers worldwide are on this [...] Researchers whose work is cited particularly frequently in specialist circles and who are considered particularly influential are identified each year in the “Highly Cited Researchers” ranking. Prof. Dr. Andreas [...] These five countries together account for more than two-thirds of all “Highly Cited Researchers”. They are followed by the Netherlands (207), Canada (196), France (146), Spain (109) and Switzerland (102). The

people and mentally ill patients, animal experiments are still indispensable. We are also working hard on alternative methods, such as stem cells, which are already providing valuable results. However, it will [...] in hand In Baden-Württemberg and the Rhine-Neckar region, there are numerous biomedical research institutions where animal experiments are carried out. Animal welfare plays an important role here. The 3R [...] research practice and solid data. To this end, the existing 3R principles are being expanded to 6Rs. The three additional principles are registration, robustness and reporting. "The original 3Rs do not cover

Researchers whose work is cited particularly frequently in specialist circles and who are considered particularly influential are identified each year in the “Highly Cited Researchers” ranking. Prof. Dr. Andreas [...] scientists worldwide identified as highly influential Publications are considered to be “highly cited” if, among other things, they are among the “top 1 percent” of the publications most cited by colleagues [...] publications from the years 2011 to 2021 were included in the evaluation. 6,938 researchers worldwide are on this year’s list. The largest number of scientists listed in 2022 continues to work in the USA (2

experiences are embedded in a personal framework. There are then follow-up tests to determine the long-term effect. The intensive moments that test subjects experience in a session of this type are also a special [...] Lia and Klaus are test subjects in the EPIsoDE-study. Their depression is considered to be treatment-resistant. This means the conventional psychopharmaceuticals barely work on them. They are two of a total [...] Gründer, who heads up the Department of Molecular Neuroimaging at CIMH. Are psychedelics the solution? Psychedelics or hallucinogens are substances that change consciousness, perception, and the emotional

Tesla technology for our research. That is why we are creating the device now. Will the two 3-Tesla devices continue to be used? Absolutely! There are a large number of research projects underway there [...] ago. Now it has become a reality. The infrastructures of the ZIPP are of central importance here and also particularly valuable, as we are making them accessible to a wider circle of DZPG researchers. Everyone [...] What are the advantages of the new 7-tesla MRI? With unprecedented spatial resolution, fewer test repetitions and greater differentiation between gray and white matter, the 7-T MRI scanner can provide

Researchers whose work is cited particularly frequently in specialist circles and who are considered particularly influential are identified each year in the “Highly Cited Researchers” ranking. Prof. Dr. Andreas [...] 21 disciplines in the natural, life and social sciences. Publications are considered highly cited if, among other things, they are among the “top 1 percent” of the most cited publications by colleagues [...] scientific field. This is an indication of the influence of a publication. 6,849 researchers worldwide are included in this year's list. In 2023, the largest number of listed researchers will continue to work

opportunity to practice exactly when the exercises are needed most,” says Schick. This is also one of the advantages of digital applications. The two researchers are encouraged by the fact that a number of EMIcompass [...] studies, six to ten sentiment surveys per day are often common, meaning that the smartphone responds with a query around every two hours. The questions are always the same and a certain routine is established [...] established when answering them. Nevertheless, not all queries are always answered. “Around 60 percent of the mood queries are answered,” says Schick. Of course, it can also happen that participants feel under

biobanks. Background to the position paper Despite this progress, existing biobanks are not yet widely used. They are, however, essential for achieving reliable research results and thus fulfilling the [...] research is often insufficient. Patients want to ensure that their samples are used responsibly and that their needs and interests are taken into account. Against this background, the GBN/GBA, the BRCA network [...] quality-assured biobanks are indispensable for the future of biomedical research,” says GBN Executive Board spokesperson PD Dr. Sara Nussbeck. “With this position paper, we are committed to optimising their