ty pattern, associated with the antidepressant response. The increases Gln/Glu ratios was found in pgACC, known as a region displaying a deficit in these ratios in subjects with depression. Evidence from [...] resting state BOLD fMRI in CUMS rats and TRD patients). Experiment with TRD patients will be performed in Tuebingen, while experiment with CUMS rats will be implemented in Mannheim DFG - Deutsche Forschu [...] Susceptibility using DREADD combined with fMRI technique (STRESS-DREADD). 02/2019-01/2020. Abstract Depression has become the second leading cause of illness-induced disability with 300 million people affected

31st World Congress of Psychiatric Genetics (WCPG), in Montreal, Canada, with the presentation: “Genetic Risk Variants Associated with Antisocial Personality Disorder in the Context of Alcohol Dependence” [...] September 27th 2022, 5pm CET / 11am EDT / 2am AEST, with the presentation: Upcoming Project: Genetics of borderline personality disorder and its associations with other psychiatric disorders and adverse childhood [...] personality traits and substance use: genetic factors underlie the association with smoking and ever use of cannabis, but not with high alcohol consumption. J Pers Disord, 26(6), 867-879. https://doi.org/10

effectively with other ongoing international initiatives, and collaborate constructively with patient groups and international consortia and experts. For example, we will actively collaborate with the patient [...] biological pathways. These signatures will be predicted in subjects with clinical/MRI biomarkers, in order to assess whether patients with extreme omics profiles show differences in functional outcomes. 2 [...] molecular alterations, are associated with schizophrenia-relevant cellular function, and yield a meaningful improvement of clinical outcome prediction when combined with the clinical/MRI biomarkers validated

found that children born to mothers with any type of diabetes, whether before or during pregnancy, had a slightly higher risk of ADHD compared to unexposed children, with a hazard ratio of 1.16. The study [...] An international research team led by the University of Hong Kong (HKUMed) and with participation of the Central Institute of Mental Health in Mannheim has just provided valuable evidence through a 20-year [...] neurodevelopmental disorders in children, which can have severe negative consequences. Individuals with ADHD are prone to poor outcomes such as emotional problems, self-harm, substance misuse, educational

explanations at the cellular level for the positive effects observed in clinical studies with psilocybin in patients with depression, addiction and post-traumatic stress disorder.” Better understanding of [...] compound that ultimately unleashes the psychoactive effect. The Mannheim research team worked directly with psilocin to investigate the neurobiological effects. In their current study, which has been published [...] for their experiments. This makes it possible to grow functional nerve cells from human stem cells. “With this modern cell system, we can investigate the effect of substances directly on human nerve cells

patients with schizophrenia have shown that NSS are associated with abnormal cortical and subcortical structure and function. Yet, it still remains unclear whether these findings are associated with neuro [...] linked with an elevated risk for developing schizophrenia. Neurological soft signs (NSS) are frequently found in psychiatric disorders of significant neurodevelopmental origin, e.g. in patients with schizophrenia [...] Second, we will apply and validate the developed method in a longitudinal analysis of 100 patients with catatonia according to ICD-11. The clinical goal is to develop robust neuroimaging biomarkers of therapy

services for people with mental illnesses and to research new therapies. The annual report provides insights into this multifaceted work. Breaking new ground in psychiatric therapy research with AI The need for [...] for new, effective therapeutic approaches to mental illness is great. With the establishment of the Hector Institute for Artificial Intelligence in Psychiatry (HITKIP), CIMH is pursuing the goal of using [...] service is the largest professional group at CIMH. The approximately 400 employees have close contact with patients, which is why they play a special role in the multi-professional teams in patient care. Doris

are in treatment 95 percent of treated HIV infections are not infectious 0 percent stigma of people with (affected by) HIV Mannheim has developed an action plan as part of the initiative. Initially, educational [...] planned especially for young people, extended testing services and monitoring of the targets set. With its testing offer, the CIMH is not only making an active contribution to achieving the goals, but [...] pioneers among the city's local partners from administration, civil society and the healthcare sector with its specific measure.

individuals that are associated with the development of depression. Almost half of these variations, which relate to 308 specific genes, have never before been associated with the disease. The identified genetic [...] study was conducted under the direction of the University of Edinburgh and King's College London and with the participation of the Central Institute of Mental Health (CIMH) in Mannheim. More accurate prediction [...] that further studies and clinical trials are needed to explore the potential of the drugs in patients with depression. The study, which was funded by the National Institutes of Health (NIH)/USA, the German

program with the necessary infrastructure,” emphasizes Meyer-Lindenberg. Part of the unique ZIPP The new device is the world's first 7 Tesla MRI Magnetom Terra.X from Siemens Healthineers with patient [...] rs is capable of imaging not only fine brain structures but also activity and metabolic processes with previously unattainable precision. In the field of therapy research, this allows the presence and [...] direct connection to the hospital rooms. The short distances make it possible to conduct research even with seriously ill patients. The ZIPP will not only be used by researchers at the CIMH, but is also a central