associations with Neuroticism and Openness but not with the other Big Five traits. Additionally, we identified a genetic link between BPD and loneliness , suggesting that individuals with a genetic pr [...] conducted a second, much larger GWAS with data from 13,024 BPD patients and 1,149,467 control participants . This study identified 11 genetic loci associated with BPD , further confirming the disorder’s [...] associated with BPD directly in postmortem brain tissue. This project aims to explore how environmental factors may influence BPD through epigenetic modifications. If you are interested in working with our data
schizophrenia with this new compound are promising, but they need to be replicated in a large group. As part of the Optimise trial, 150 patients with a first psychosis will be treated with either cannabidiol [...] historical convenience cohorts with crude measures of environmental factors and clinical outcomes, the focus in EU-GEI will be on recruitment of new, family-based clinical samples with state-of-the-art assessments [...] historical convenience cohorts with crude measures of environmental factors and clinical outcomes, the focus in EU-GEI will be on recruitment of new, family-based clinical samples with state-of-theart assessments
ty pattern, associated with the antidepressant response. The increases Gln/Glu ratios was found in pgACC, known as a region displaying a deficit in these ratios in subjects with depression. Evidence from [...] resting state BOLD fMRI in CUMS rats and TRD patients). Experiment with TRD patients will be performed in Tuebingen, while experiment with CUMS rats will be implemented in Mannheim DFG - Deutsche Forschu [...] Susceptibility using DREADD combined with fMRI technique (STRESS-DREADD). 02/2019-01/2020. Abstract Depression has become the second leading cause of illness-induced disability with 300 million people affected
ty pattern, associated with the antidepressant response. The increases Gln/Glu ratios was found in pgACC, known as a region displaying a deficit in these ratios in subjects with depression. Evidence from [...] resting state BOLD fMRI in CUMS rats and TRD patients). Experiment with TRD patients will be performed in Tuebingen, while experiment with CUMS rats will be implemented in Mannheim DFG - Deutsche Forschu [...] Susceptibility using DREADD combined with fMRI technique (STRESS-DREADD). 02/2019-01/2020. Abstract Depression has become the second leading cause of illness-induced disability with 300 million people affected
administered to N=22 patients with BPD while they receive residential Dialectical Behavior Therapy (DBT) treatment. In addition, outcomes are assessed from a control group with same sample size who do not [...] Abstract In the planned set of studies, we will use neurofeedback to augment psychotherapy in patients with Borderline Personality Disorder (BPD) at risk for failure to benefit from psychotherapy treatment [...] the protocol, three sessions of real-time fMRI neurofeedback will be administered to N=10 patients with BPD during DBT treatment. Neurofeedback will be used to consolidate skills the patients learned during
cue-induced brain activation in male patients with alcohol use disorder: A randomized, placebo-controlled crossover study examining male and female patients with AUD . Psychoneuroendocrinology . 2025 177:107456 [...] . Intranasal oxytocin blunts amygdala response to negative affective stimuli in males and females with alcohol use disorder: a randomized controlled cross-over trial . Psychopharmacology (Berl) . 2025
ty pattern, associated with the antidepressant response. The increases Gln/Glu ratios was found in pgACC, known as a region displaying a deficit in these ratios in subjects with depression. Evidence from [...] resting state BOLD fMRI in CUMS rats and TRD patients). Experiment with TRD patients will be performed in Tuebingen, while experiment with CUMS rats will be implemented in Mannheim DFG - Deutsche Forschu [...] Susceptibility using DREADD combined with fMRI technique (STRESS-DREADD). 02/2019-01/2020. Abstract Depression has become the second leading cause of illness-induced disability with 300 million people affected
31st World Congress of Psychiatric Genetics (WCPG), in Montreal, Canada, with the presentation: “Genetic Risk Variants Associated with Antisocial Personality Disorder in the Context of Alcohol Dependence” [...] September 27th 2022, 5pm CET / 11am EDT / 2am AEST, with the presentation: Upcoming Project: Genetics of borderline personality disorder and its associations with other psychiatric disorders and adverse childhood [...] personality traits and substance use: genetic factors underlie the association with smoking and ever use of cannabis, but not with high alcohol consumption. J Pers Disord, 26(6), 867-879. https://doi.org/10
patients with schizophrenia have shown that NSS are associated with abnormal cortical and subcortical structure and function. Yet, it still remains unclear whether these findings are associated with neuro [...] linked with an elevated risk for developing schizophrenia. Neurological soft signs (NSS) are frequently found in psychiatric disorders of significant neurodevelopmental origin, e.g. in patients with schizophrenia [...] Second, we will apply and validate the developed method in a longitudinal analysis of 100 patients with catatonia according to ICD-11. The clinical goal is to develop robust neuroimaging biomarkers of therapy
effectively with other ongoing international initiatives, and collaborate constructively with patient groups and international consortia and experts. For example, we will actively collaborate with the patient [...] biological pathways. These signatures will be predicted in subjects with clinical/MRI biomarkers, in order to assess whether patients with extreme omics profiles show differences in functional outcomes. 2 [...] molecular alterations, are associated with schizophrenia-relevant cellular function, and yield a meaningful improvement of clinical outcome prediction when combined with the clinical/MRI biomarkers validated
