preclinical models of cognitive dysfunction. 10/2021-03/2023. Abstract Recurrent neural networks (RNN) are a class of artificial neural networks that can be trained with empirical behavioral data to emulate
to what extent the effects of the knock-out on brain structure and function are reversible by treatment. Both approaches are complementary and serve our long-term goal to understand the interaction of [...] has been hard to take these findings from the bench to the clinic. We think there are three major bottlenecks that are holding the field back: i) a lack of pathophysiologically-accurate animal models guiding [...] to any other approved procedure. Thus, new treatment options for therapy resistant depression (TRD) are urgently needed. A better understanding of the underlying brain circuits of depression has led to the
for robust science. Infrastructure, knowledge and incentives for Open Science The CIMH and the GRN are working together to improve the quality, robustness, reproducibility and transparency of research.
exceptional colleagues from Germany. This unique honor is a reminder of how important our efforts are to reduce the burden of mental illness”, stated Weinberger. The Heinrich Lanz Prize for Translational [...] the ceremony to mark the 50th anniversary of the Central Institute of Mental Health in Mannheim. “We are honored by the Heinrich Lanz Foundation's decision to award this prize in the context of our anniversary
pmental disorders in children, which can have severe negative consequences. Individuals with ADHD are prone to poor outcomes such as emotional problems, self-harm, substance misuse, educational undera [...] highlighted the need for deliberate consideration and future research. “This implies that women who are planning pregnancy should look at their holistic risk profile rather than focusing solely on gestational
selected brain areas and dysfunctional neuronal network activity. Since brain samples from patients are not accessible for mechanistic biomarker validation in vitro, we apply neurons differentiated from [...] partners LMU and CIMH. Diagnostic and imaging data as well as blood samples of the corresponding patients are at hand and serve for sequencing blood transcriptomes and the establishment of multi-modal disease [...] The classic form is caused by mutations in the transcriptional regulator MECP2. Effective therapies are not currently available and gene editing based on CRISPR/Cas9 combined with Homology Directed Repair
to what extent the effects of the knock-out on brain structure and function are reversible by treatment. Both approaches are complementary and serve our long-term goal to understand the interaction of [...] has been hard to take these findings from the bench to the clinic. We think there are three major bottlenecks that are holding the field back: i) a lack of pathophysiologically-accurate animal models guiding [...] to any other approved procedure. Thus, new treatment options for therapy resistant depression (TRD) are urgently needed. A better understanding of the underlying brain circuits of depression has led to the
safety instructions are hypothesized to inhibit fear acquisition and/or to accelerate extinction learning. Attentional processes, psychophysiological responding, and behavioral measures are examined to link [...] can be amazingly persistent – even when the aversive outcomes are never experienced – the implications for a range of anxiety disorders are evident. Young Researchers Award, ZI, Mannheim : Ecological momentary [...] pain perception, which are related to dissociation and self-injurious behavior. However, it is unknown if these alterations, which occur primarily in aversive affective situations, are a core variable or some
intensive efforts by the pharmaceutical industry, therapeutic regimes available to treat these disorders are largely aimed at relieving symptoms and work best at slowing or halting the underlying disease progression [...] of untreated psychosis during which the disease severity increases before appropriate therapeutics are prescribed to first episode schizophrenics. It is worth noting that, where early treatment has been [...] produced in 1950. Since then, numerous new anti-psychotic drugs have been introduced. Most of these drugs are largely equal in efficacy and differ mainly in profile of side effects. Up till now, it has remained
funding, which is two million more than in 2021. In the high-funding research projects, researchers are looking at psychedelics in the treatment of treatment-resistant depression, the development of chronic
