progress in the understanding of phantom limb pain (PLP), we still do not know which factors are antecedents and which are consequences of the pain and how central, peripheral and psychological factors interact [...] alcohol abuse are a major medical challenge in chronic pain, especially in female pain patients with adverse childhood experiences. However, it is unknown whether these comorbidities are caused by specific [...] Germany in the 2last years speak languages such as Arabic that are not understood by the resident therapeutic community, interpreters are scarce and not available around the clock or in emergency situations
novel treatment targets. We are starting with addictions because the societal needs are high, the animal models are best established, and the translational strategies requierd are most clear; once in place [...] alcohol abuse are a major medical challenge in chronic pain, especially in female pain patients with adverse childhood experiences. However, it is unknown whether these comorbidities are caused by specific [...] addicted. Substance use disorders (SUDs) generate the largest disease burden and are categorized by DSM-5 and ICD11. SUDs are defined by compulsive drug use, craving, and re-lapses that can occur even after
7. Abstract Mental disorders are leading causes of disability, absence from work and premature retirement in Europe. While magnetic resonance imaging (MRI) facilities are broadly available and a vast research [...] A major problem is that mental illnesses are currently diagnosed as discrete entities defined clinically. Instead, recent results show that mental disorders are best understood as quantitative alterations [...] has been hard to take these findings from the bench to the clinic. We think there are three major bottlenecks that are holding the field back: i) a lack of pathophysiologically-accurate animal models guiding
psychotherapy are well established and evaluated therapeutic options. In most cases psychotropic medication with psychostimulants is terminated in late adolescence. In contrast, there are no controlled [...] to be about 5% and in adulthood the prevalence is indicated to 2%. Comorbidity rates in adult ADHD are very high with substance abuse, antisocial behaviour, affective disorders and personality disorders
progress in the understanding of phantom limb pain (PLP), we still do not know which factors are antecedents and which are consequences of the pain and how central, peripheral and psychological factors interact [...] interventions do not sufficiently address comorbid disorders, are provided too late, do not reach the majority of addicted subjects and are not adjusted with respect to environmental stressors, affective [...] pain perception, which are related to dissociation and self-injurious behavior. However, it is unknown if these alterations, which occur primarily in aversive affective situations, are a core variable or some
01/2020-12/2023. Abstract Similar to psychiatric disorders, rodent models for psychiatric diseases are stigmatized and regarded as particularly stressful. However, scientific evaluation of this assumption [...] and pain-related disorders. Here, we suggest performing such an evaluation and use simple tests that are sensitive when well-being of rodents is compromised, such as tests for nesting, burrowing, self care [...] in western countries. About 200.000-300.000 of the 800.000 patients with schizophrenia in Germany are unable to work. Schizophrenia shows a characteristic onset of symptoms during late adolescence/early
affective disorders are heterogeneous clinical conditions, it is unlikely that single genetic variants are associated with categorial disease. A more plausible hypothesis is that such variants are associated with [...] affective disorders are heterogeneous clinical conditions, it is unlikely that single genetic variants are associated with categorial disease. A more plausible hypothesis is that such variants are associated with [...] identification of pathogenic copy number variants that are associated with high risks for schizophrenia), major efforts to establish such testing are now underway. The publication of the major advances in
7. Abstract Mental disorders are leading causes of disability, absence from work and premature retirement in Europe. While magnetic resonance imaging (MRI) facilities are broadly available and a vast research [...] A major problem is that mental illnesses are currently diagnosed as discrete entities defined clinically. Instead, recent results show that mental disorders are best understood as quantitative alterations [...] has been hard to take these findings from the bench to the clinic. We think there are three major bottlenecks that are holding the field back: i) a lack of pathophysiologically-accurate animal models guiding
modulates different behaviors related to sociality, sexuality, fear, pain and others. Its effects are mediated via its action throughout the brain as a neuropeptide as well as throughout the periphery
neuronal ensembles in reward-seeking processes. 04/2021-03/2022. Abstract Our daily life activities are driven by rewards which can be conditioned to specific stimuli and environmental contexts. Reward-seeking [...] alcoholism, including advanced conditional knockout mice and viral vector gene transfer. Our experiments are aimed 1) to establish the intracellular co-localization of D1 and CRHR1 receptors in the amygdala of [...] improve our understanding of amygdala function in alcohol dependence, to identify mechanisms that are specific for this region and, in a broader perspective, to contribute to a better understanding of
