namely a preclinical multicenter placebo controlled trial in rats with a step-wise translation into a naturalistic pilot trial with ambulatory assessment in alcoholic patients. As a comparator, we will [...] in animals, and which can be transferred to humans. With our highly interdisciplinary EU consortium (PIs from seven European countries and Israel with outstanding expertise) it is expected that after having [...] placebo vs acamprosate – which is a clinically effective medication. These data will be contrasted with a 3-arm design in male and female alcohol addicted rats where two doses of intranasally applied OXY

Evaluation of a Smartphone App Intervention with Telephone Guidance as Transitional Support from Inpatient Treatment to Continuing Care for Individuals with Alcohol Use Disorder: Results from a Randomized

reduce cognitive deficits and substance craving in individuals with substance use disorders (SUD) of different kinds. In individuals with SUD, functional neuroimaging and neuropsychological tasks have [...] and associated underlying neuronal networks observed to be affected in individuals with AUD overlap significantly with those that could be strengthened by chessbased cognitive training or formal chess. [...] changes. Further, by applying tDCS over the dorsolateral prefrontal cortex (DLPFC) in individuals with SUD, the characteristic craving for a substance can be reduced. As there are divergent findings on

Together with Heidelberg University’s Institute of Sports and Sports Sciences the Central Institute of Mental Health (CIMH) is hosting a one-day symposium, exploring how physical activity impacts brain [...] s — Lemye Zehirlioglu, Nicole Frisch, Michaela Kroth, Daniela Ramirez Butavand, and Lea Nitzpon — with support from the heiDOCS Doctoral Initiative Grant of the Graduate Academy Heidelberg. Interested

(Mannheim Risk Child Study. This examines the mental development of participants with different early childhood risk exposures – with the aim of deriving recommendations for improving the prevention, early detection

in adult patients with alcohol addiction, (iv) to expand the NGFNplus sample by including a new set of healthy subjects with high genetic risk (1st degree relatives of patients with alcohol addiction) [...] characterize longitudinal outcomes in patients with alcohol addiction (5 years following our index session) and to complement the NGFN-sample with an add-on study with 1st degree relatives that will allow us [...] reduce cognitive deficits and substance craving in individuals with substance use disorders (SUD) of different kinds. In individuals with SUD, functional neuroimaging and neuropsychological tasks have

of the virus,” says Rainer Spanagel. The lung is considered a very susceptible organ for infection with SARS-CoV2. Thus, acute respiratory distress syndrome (ARDS) often occurs in cases of serious covid-19 [...] triggered that kills the virus in the cells. One of the initial factors for this cascade is MAS, a gene with anti-inflammatory effect, which is therefore a protective factor in relation to the corona disease [...] may have a potential effect on overall corona infection risk and favoring complications associated with the disease. Clarifying epidemiological studies in patients are urgently needed to further investigate

significant reduction in animal experiments at the ZI. With the new 3R Center, we can identify further potential and strengthen animal protection together with our partners," says Prof. Dr. Rainer Spanagel , [...] animal experiments also take place. Therefore, the issue of animal welfare is of particular importance. With the 3R Center Rhine-Neckar, the Baden-Württemberg Ministry of Science, Research and the Arts is now [...] continuously address the issue of animal welfare but also to improve the overall quality of research. With its focus on 'Refine' and 'Reduce', the 3R Center Rhine-Neckar ideally complements the '3R Center

olfactory inputs have the most direct access to the limbic system and evoke innate and learned behaviors with lasting aversive and appetitive memories. The olfactory system maintains stem cell niches providing [...] t period. In parallel, we study the postnatal developmental trajectory of the dopaminergic system with similar aims to dissect genetic and environmental influences on mature circuit properties. These limbic

Open-Label, Study To Evaluate The Long-Term Safety Of Ecopipam Tablets In Children, Adolescents And Adults With Tourette’s Disorder. 07/2024-07/2027. Grimmer Y, Koopmann A. Dietmar Hopp Stiftung gGmbH 1DH2311081: [...] will be involved in the optimization of domain-specific (i.e. task-fMRI) analysis pipelines, along with the harmonization of the data to a common standard. Building upon these analyses, CIMH will contribute [...] stratification markers based on existing EU-AIMS and new LEAP data sets as well as by integrating data with other existing cohorts. Häge A. Servier Deutschland GmbH : Bumetanide in Autism. 12/2018-12/2021.