individuals, biobanking, data protection, etc.) have been addressed within the ELSI projects of the Human Genome Project. While standards have been set for certain aspects (e.g. biobanking and data protection) [...] diagnostic boundaries. Background and own previous work: The heritability of bipolar disorder (BD) has been reported to be as high as 80%, while that of major depressive disorder (MDD) ranges between 40 and [...] be analysed throughout the course of the FOR, once a substantial number of the study subjects have been characterized with the PsychChip. The two genes of interest (NCAN, BDNF) will also be analysed in

temporal trajectories and related pathomechanisms across individuals and symptom clusters. PMDD has often been treated as a homogeneous condition across individuals and stable over cycles in both clinical and [...] negative experiences with them. Aversive anticipations, as triggered by social communication, have been shown to reliably activate physiological defense mechanisms. However, very little is known about how [...] negative emotions in patients with NSSI. However, proximal antecedents and consequences of NSSI have not been studied comprehensively in the daily life of BPD patients so far. Consequently, we aim to investigate

and depression (S&D) every year, there have been few truly innovative new chemical entities (NCEs) which have made it to the clinic. While there has been a tremendous explosion of new knowledge: dozens [...] pathways identified, numerous imaging findings differentiating patients from controls, yet, it has been hard to take these findings from the bench to the clinic. We think there are three major bottlenecks

chronic alcohol exposure. However, a detailed assignment of those changes to specific cell types has not been performed due to technical limitations and lack of appropriate tissue. In this planned consortium

basis that emphasizes one behaviour over another. Recently, in healthy young participants, sleep has been shown to interact with these reward signals that strengthen rewarded information more strongly than [...] evaluate particularly positive information referenced to themselves as less positive and this has been related to an internal, negative and global attributional style. They feel less included during positive

chronic alcohol intake leads to neuroinflammation that in turn triggers addictive behaviour. It has been shown that intranasal delivery of mesenchymal stem cell-derived exosomes reduces relapse behaviour [...] description of our consortium in Addiction Biology (Spanagel et al., 2014; this article has already been cited 20 times), (iii) our website (www.sysmedalc.eu), (iv) meetings and reports (kick-off meeting [...] (BPD). The experience of social rejection by others is a major source of distress in humans and has been implicated in the development of various psychiatric disorders including BPD. BPD patients often report

established the routine generation of iPSC lines from mouse and humans (almost 20 m/hiPSC lines have been generated), (iii) analyzed opioid and dopamine system adaptations at both transcriptional and protein

neural networks that trigger aggressive behavior. In terms of treatment, only limited efficacy has been reported, possibly attributable to the presence of distinct (e.g. arousal- specific) subgroups within [...] functioning contributes to the emergence of aggressive behavior. Moreover, specific arousal patterns have been shown to distinguish CD patients with and without CU traits, which paves the way for an individualized [...] prefrontal-amygdala connectivity during extinction. A polymorphism on the neurogranin gene, which has been associated with high risk for schizophrenia and memory disturbance, was found to predict hippocampal

chronic alcohol intake leads to neuroinflammation that in turn triggers addictive behaviour. It has been shown that intranasal delivery of mesenchymal stem cell-derived exosomes reduces relapse behaviour

07 - Neural circuits involved in Phantom Limb Pain . 07/2019-06/2023. Abstract Although there has been much progress in the understanding of phantom limb pain (PLP), we still do not know which factors