09/2012-02/2015. Abstract Schizophrenia patients suffer from a broad variety of cognitive deficits that are very often resistant to antipsychotic treatment and interfere with the social and vocational rehabilitation [...] Besides the domains represented in the MATRICS battery, it has been shown that metacognitive capacities are impaired in schizophrenia, leading to a reduced ability to select appropriate responses, to appraise [...] alterations (4;5), and finally deficits in mentalizing and social cognition („theory of mind“: ToM) (6;7), are thought to contribute to development and maintenance of delusions (8-10). Specific therapeutic int
social cues. In particular, we found that BPD patients experience happy faces as less intense and are less confident during their evaluation. They evaluate particularly positive information referenced [...] positive social information in memory, and the guidance of action based on positive social experiences are impaired in BPD patients. Effects will be measured by means of overt behavior, psychophysiological [...] al., 2009). There is ample evidence that after traumatic experience acute memories for these events are repeatedly reactivated for a certain amount of time which allows for the incorporation of new information
progress in the understanding of phantom limb pain (PLP), we still do not know which factors are antecedents and which are consequences of the pain and how central, peripheral and psychological factors interact [...] clinically-orientated approaches to understanding behaviour (Mannheim). The overall projects goals are to: a) develop a new model of pain-reward interactions that explains data from behavioural experiments [...] experimentally testable versions, we wish to examine to what extend the experiences of pain and suffering are centered in the private experience or in a person’s social and cultural interaction with the others
Germany in the 2last years speak languages such as Arabic that are not understood by the resident therapeutic community, interpreters are scarce and not available around the clock or in emergency situations [...] addicted. Substance use disorders (SUDs) generate the largest disease burden and are categorized by DSM-5 and ICD11. SUDs are defined by compulsive drug use, craving, and re-lapses that can occur even after [...] and stimulants. One fundamental question in psy-chiatric research is: “How distinct are the different SUDs and what are the shared pathological phenomena?” Here we aim to determine the extent to which alcohol
human population, but treatment options are very limited. Rational strategies for design and development of novel, evidence based therapies for alcohol addiction are still missing. Alcohol dependence is
Serotonin and GABA-B receptots in anxiety . 02/2008-01/2012. Abstract GABAergic and serotoninergic systems are key players in the control of anxiety states but the precise bases for their action has remained elusive
approaches across species, my work aims to provide mechanistic insights into how positive emotions are generated in the brain, contributing to a better understanding of affective processes relevant to mental
progress in the understanding of phantom limb pain (PLP), we still do not know which factors are antecedents and which are consequences of the pain and how central, peripheral and psychological factors interact [...] human population, but treatment options are very limited. Rational strategies for design and development of novel, evidence based therapies for alcohol addiction are still missing. Alcohol dependence is [...] interventions do not sufficiently address comorbid disorders, are provided too late, do not reach the majority of addicted subjects and are not adjusted with respect to environmental stressors, affective
human population, but treatment options are very limited. Rational strategies for design and development of novel, evidence based therapies for alcohol addiction are still missing. Alcohol dependence is [...] Better treatments and prediction approaches that can be easily translated into the clinical situation are warranted. In our e:Med funded SysMedAlcoholism consortium we have identified early warning signs and [...] system in alcoholic patients suggesting OXY as a candidate medication to reduce relapse. Here our Goals are (i) to demonstrate the clinical applicability of OXY and (ii) to computationally predict elapse and
Lourdusamy A, Havekes R, Abel T, Müller CP , Radwanska K. Hippocampal Cofilin and CFL1 gene variants are linked to Alcohol Use Disorder phenotypes . Mol Psychiatry . 2025 Sep 11. [Epub ahead of print] Türkmen
