better treatments and prediction approaches that can be easily translated into the clinical situation are warranted. One major hypothesis in alcohol research is that chronic alcohol intake leads to neuroi [...] Better treatments and prediction approaches that can be easily translated into the clinical situation are warranted. In our e:Med funded SysMedAlcoholism consortium we have identified early warning signs and [...] system in alcoholic patients suggesting OXY as a candidate medication to reduce relapse. Here our Goals are (i) to demonstrate the clinical applicability of OXY and (ii) to computationally predict elapse and

human population, but treatment options are very limited. Rational strategies for design and development of novel, evidence based therapies for alcohol addiction are still missing. Alcohol dependence is [...] unrewarded information. The present research aims to show that, during learning, mesolimbic reward signals are bound to hippocampal memory representations of events and actions that led to rewards and that, during [...] ng between cultures gains tremendously in importance. Recent studies, however, showed that people are better in understanding emotions and mental states of people from their own than from another culture

Zur Forschung Experiences are imprinted into synaptic connections during postnatal development. This experience-dependent synaptic wiring appears to develop on the background of genetically-determined

Lourdusamy A, Havekes R, Abel T, Müller CP, Radwanska K. Hippocampal Cofilin and CFL1 gene variants are linked to Alcohol Use Disorder phenotypes . Mol Psychiatry . 2025 Sep 11. [Epub ahead of print] Wenzel

preclinical models of cognitive dysfunction. 10/2021-03/2023. Abstract Recurrent neural networks (RNN) are a class of artificial neural networks that can be trained with empirical behavioral data to emulate

to what extent the effects of the knock-out on brain structure and function are reversible by treatment. Both approaches are complementary and serve our long-term goal to understand the interaction of [...] has been hard to take these findings from the bench to the clinic. We think there are three major bottlenecks that are holding the field back: i) a lack of pathophysiologically-accurate animal models guiding [...] to any other approved procedure. Thus, new treatment options for therapy resistant depression (TRD) are urgently needed. A better understanding of the underlying brain circuits of depression has led to the

selected brain areas and dysfunctional neuronal network activity. Since brain samples from patients are not accessible for mechanistic biomarker validation in vitro, we apply neurons differentiated from [...] partners LMU and CIMH. Diagnostic and imaging data as well as blood samples of the corresponding patients are at hand and serve for sequencing blood transcriptomes and the establishment of multi-modal disease [...] The classic form is caused by mutations in the transcriptional regulator MECP2. Effective therapies are not currently available and gene editing based on CRISPR/Cas9 combined with Homology Directed Repair

to what extent the effects of the knock-out on brain structure and function are reversible by treatment. Both approaches are complementary and serve our long-term goal to understand the interaction of [...] has been hard to take these findings from the bench to the clinic. We think there are three major bottlenecks that are holding the field back: i) a lack of pathophysiologically-accurate animal models guiding [...] to any other approved procedure. Thus, new treatment options for therapy resistant depression (TRD) are urgently needed. A better understanding of the underlying brain circuits of depression has led to the

safety instructions are hypothesized to inhibit fear acquisition and/or to accelerate extinction learning. Attentional processes, psychophysiological responding, and behavioral measures are examined to link [...] can be amazingly persistent – even when the aversive outcomes are never experienced – the implications for a range of anxiety disorders are evident. Young Researchers Award, ZI, Mannheim : Ecological momentary [...] pain perception, which are related to dissociation and self-injurious behavior. However, it is unknown if these alterations, which occur primarily in aversive affective situations, are a core variable or some

intensive efforts by the pharmaceutical industry, therapeutic regimes available to treat these disorders are largely aimed at relieving symptoms and work best at slowing or halting the underlying disease progression [...] of untreated psychosis during which the disease severity increases before appropriate therapeutics are prescribed to first episode schizophrenics. It is worth noting that, where early treatment has been [...] produced in 1950. Since then, numerous new anti-psychotic drugs have been introduced. Most of these drugs are largely equal in efficacy and differ mainly in profile of side effects. Up till now, it has remained