. Intranasal oxytocin blunts amygdala response to negative affective stimuli in males and females with alcohol use disorder: a randomized controlled cross-over trial . Psychopharmacology (Berl) . 2025

Translational Neuroscience with focus on: (1) Genetic and environmental underpinnings of neuropsychiatric diseases; (2) Endogenous neuroprotection and neuroregeneration as therapeutic strategies for patients:

Scholz I, Koppe G, Kirsch P, Gerchen M . Self-referential belief shares common neural correlates with general belief . Sci Rep . 2025 15(1):2137. Sacu S , Hermann A, Banaschewski T, Gerchen M , Holz NE

will be validated by a new optogenetic tool, which allows selectively modifying neuronal ensembles with improved temporal control and specificity. In summary, our approach will give insight into the function [...] hyper-dopaminergic state that drives alcohol craving (Hirth et al., 2015), and finally (iv) established with a collaborator from NIAAA, Bethesda USA, a database of brain miRNA profiles from the prefrontal cortices [...] there exist DA D1 and CRHR1 receptor rich neuronal populations - the intercalating cell masses (ICM) - with important gating functions for intra-amygdala signal flow. We hypothesize that within these cells

in animals, and which can be transferred to humans. With our highly interdisciplinary EU consortium (PIs from seven European countries and Israel with outstanding expertise) it is expected that after having [...] missing. Alcohol dependence is characterized by cycles of excessive alcohol consumption, interspersed with intervals of abstinence, and frequent relapses. Relapse is a key element of this disease process and

vague and correlating the effects of neuromodulators with specific behavioral situations is difficult. Olfactory system modulation by oxytocin provides with a unique opportunity to directly ask how neural [...] learning in those situations. We here propose the fact that oxytocin release can be reliably associated with certain behavioral states to use it as a model system for modulation of brain states and associated [...] task periods during which dopamine input is most crucial, how dopamine neuron activity is coordinated with PFC activity as the task progresses, and how it impacts on various subcomponents of rule learning

analytical and clinical validity. The latter depends on qualifying measures linking peripheral biomarkers with a biological process and clinical endpoints of schizophrenia. Thus, biomarker signatures identified [...] faithfully represent the genetic background of individual patients. To this end, iPSC clones from patients with schizophrenia will be delivered by partners LMU and CIMH. Diagnostic and imaging data as well as blood [...] isolating and sequencing of individual nuclei from snap-frozen brain samples obtained from patients with other neuropsychiatric diseases. In parallel we will use standardized human iPSC-derived forebrain

administered to N=22 patients with BPD while they receive residential Dialectical Behavior Therapy (DBT) treatment. In addition, outcomes are assessed from a control group with same sample size who do not [...] recently stored memory. We will examine healthy subjects and unmedicated patients with high proneness for dissociation (patients with BPD and complex PTSD). Differential fear conditioning will be applied following [...] Abstract In the planned set of studies, we will use neurofeedback to augment psychotherapy in patients with Borderline Personality Disorder (BPD) at risk for failure to benefit from psychotherapy treatment

isolating and sequencing of individual nuclei from snap-frozen brain samples obtained from patients with other neuropsychiatric diseases. In parallel we will use standardized human iPSC-derived forebrain [...] WP2: A human brain Organoid-based addiction circuitry to investigate molecular changes associated with SUDs. 11/2019-10/2022. Ladewig J. DFG - Deutsche Forschungsgemeinschaft LA 2933/3-1 : MECPer-3D: [...] MECP2. Effective therapies are not currently available and gene editing based on CRISPR/Cas9 combined with Homology Directed Repair appears an appealing option for the development of new therapeutic approaches

Leitung Prof. Dr. med. Dr. med. vet. Hannelore Ehrenreich E-Mail Beschreibung Translational Neuroscience with focus on: (1) Genetic and environmental underpinnings of neuropsychiatric diseases; (2) Endogenous