Meyer-Lindenberg A. EU - Europäische Union HEALTH-F2-2013-602805: Aggressotype - WP1 Neural correlates of aggression – human studies . 11/2013-09/2018.
WP1 Neural correlates of aggression – human studies WP1 evaluates the neural substrates of impulsive and instrumental aggression by identifying neural, neurocognitive and biomarker mechanisms underlying aggressive/antisocial behaviour in high-risk children and adolescents (subjects with ADHD). Furthermore, a new sample of children with Conduct Disorder (CD), as well as of adolescents with CD is collected. In addition, this WP measures cognitive, physiological and motor components of empathy in children and adolescents with CD and examines whether different empathy components are differentially affected across the various aggression subtypes. Finally, WP1 integrates the findings of the different tasks and examines the common (cross-disorder) and the disorder-specific correlates of the aggressive/antisocial behaviour.
Meyer-Lindenberg A. EU - Europäische Union 115300: EU-AIMS - European Autism Interventions – A Multicentre Study for Developing New Medications. 04/2012-03/2017.
There are no effective pharmacological treatments for the core symptoms of autism spectrum disorder (ASD), and our understanding of the pathophysiology of the disease is poor. Research is hampered by a lack of valid and reliable cellular assays and animal models; an absence of tests that demonstrate efficacy in healthy volunteers from childhood to adulthood; and the reliance of clinical trials on biologically heterogeneous groups of patients as operationally-defined by DSM/ICD10 categories. Further, even if novel treatments were developed, there is no EU platform to test them clinically. Despite these limitations, the recent identification of genetic risk factors for ASD provides unique opportunities to substantially improve this situation. We therefore propose an integrated, translational, effort to achieve key objectives for ASD research, which will deliver new research tools and standards for clinical development, and pave the way for drug discovery and clinical trials. To implement this integrated effort, 13 leading ‘hubs’ in European institutions (with linked ‘satellites’ across the EU) have partnered with Autism Speaks (the world’s leading Autism Research Charity), three SMEs and EFPIA to: a) develop cellular assays and animal models based on confirmed genetic risks, and utilize these models to focus on translational endophenotypes for facilitating new drug discovery; b) validate biomarkers and patient group stratification to optimize conditions for clinical trials; and c) develop a sustainable EU-wide clinical infrastructure to promote research and development of new drugs. We will couple this integrated research effort with the development of new training opportunities and the implementation of new analytical approaches. One of Europe’s leading scientific management SMEs (GABO:mi) will facilitate the management of EU-AIMS and a distinguished international Scientific Advisory Board will provide input and guidance to ensure that we integrate effectively with other ongoing international initiatives, and collaborate constructively with patient groups and international consortia and experts. For example, we will actively collaborate with the patient group, Autism Europe, and the Autism Genetic Resource Exchange (AGRE). Thus, we propose an innovative program that will have genuine impact on academic, pharmaceutical, and regulatory stakeholders in the field of ASD. By the end of the 5 year project we expect to provide novel validated cellular assays, animal models, new fMRI methods with dedicated analysis techniques, new PET radioligands, as well as new genetic and proteomic biomarkers for patient-segmentation or individual response prediction. We will provide a research network that can rapidly test new treatments in man. These tools should provide our EFPIA partners with an added competitive advantage in developing new drugs for ASD.