models with a GWAS approach in humans and have proven to be very successful in generating priority candidate gene lists. However, the demonstration of a causal relationship of a candidate gene with a given [...] from massive gene expression profiling in animals that underwent chronic nicotine self-administration with the human genetic data sets deriving from the German Priority Programme on Nicotine Research SPP1226
Scholz I, Koppe G , Kirsch P, Gerchen M . Self-referential belief shares common neural correlates with general belief . Sci Rep . 2025 15(1):2137. Bähner F , Popov T, Boehme N, Hermann S, Merten T, Zingone [...] Dietrich S, Durstewitz D , Reininghaus U , Krumm S. Health-Promoting Effects and Everyday Experiences With a Mental Health App Using Ecological Momentary Assessments and AI-Based Ecological Momentary Interventions
17. [Epub ahead of print] Lenz B , Derntl B. Sex-sensitive and gender-sensitive care for patients with mental disorders . Lancet Psychiatry . 2025 12(4):244-246. Epub 2024 Oct 24. Nayman S, Niedtfeld I [...] administration reduces alcohol craving and cue-induced nucleus accumbens activation in individuals with alcohol use disorder: the double-blind randomized controlled ICONIC trial . Mol Psychiatry . 2025
trauma experience) will be enhanced by including participants with moderate to high levels of social and trait anxiety, as well as individuals with adverse childhood experiences. In addition, an intensified [...] physiological responding were observed. In healthy participants, these biases showed high covariance with self-reported social and trait anxiety. The second funding period will focus on the role of threat-related [...] face perception and social learning. Taken together, a dimensional transdiagnostic approach is chosen with a focus on threat-related biases in person perception – from healthy functional to the anxiety disorder
three steps: 1) A prospective cohort study, comparing the activity of the centres endowed with a typical SCU-B with that of the other participating centres lacking this facility; the efficacy and the cos [...] quality of life of persons with dementia, lessening caregivers' burden, possibly delaying institutionalisation 2) A conference aiming at adapting the SCU-B model in accordance with the results of the cohort [...] will be to assess the effectiveness of an intervention, the special medical care unit for patients with BPSD (SCU-B), that, albeit already implemented in some European countries, is not widespread and has
context conditioning and that larger amygdala volume is associated with better cue conditioning, whereas cue conditioning is reduced with larger hippocampal volume. We also found that polymorphisms related [...] been associated with high risk for schizophrenia and memory disturbance, was found to predict hippocampal activation during context conditioning. In addition, traumatized persons with and without PTSD [...] stress analgesia in the patients with PTSD and this was linked to enhanced activation in the rostral anterior cingulate. We also observed better second order conditioning with trauma cues as unconditioned
in adult patients with alcohol addiction, (iv) to expand the NGFNplus sample by including a new set of healthy subjects with high genetic risk (1st degree relatives of patients with alcohol addiction) [...] characterize longitudinal outcomes in patients with alcohol addiction (5 years following our index session) and to complement the NGFN-sample with an add-on study with 1st degree relatives that will allow us [...] reduce cognitive deficits and substance craving in individuals with substance use disorders (SUD) of different kinds. In individuals with SUD, functional neuroimaging and neuropsychological tasks have
in adult patients with alcohol addiction, (iv) to expand the NGFNplus sample by including a new set of healthy subjects with high genetic risk (1st degree relatives of patients with alcohol addiction) [...] characterize longitudinal outcomes in patients with alcohol addiction (5 years following our index session) and to complement the NGFN-sample with an add-on study with 1st degree relatives that will allow us [...] namely a preclinical multicenter placebo controlled trial in rats with a step-wise translation into a naturalistic pilot trial with ambulatory assessment in alcoholic patients. As a comparator, we will
Amide Hydrolase in Comorbid Borderline Personality Disorder and Major Depressive Disorder: Imaging with [C]CURB PET . Neuropharmacology . 2025 273:110436. Epub 2025 Mar 28. Dwyer JB, Schmahl C , Makinodan [...] Sommer S, Wruck J, Jelaska A, Adeniji A, Goodman M. Efficacy and Safety of BI 1358894 in Patients With Borderline Personality Disorder: Results of a Phase 2 Randomized, Placebo-Controlled, Parallel Group
style as a digital marker for depression severity: An ambulatory assessment pilot study in patients with depressive disorder undergoing sleep deprivation therapy . Acta Psychiatr Scand . 2025 151(3):348-357 [...] Ebner-Priemer U , Zeeck A, Reichert M . Relationship between nonexercise activity and mood in patients with eating disorders . Acta Psychiatr Scand . 2025 151(3):448-462. Epub 2024 Sep 7. Ruf A, Ahrens KF,
